22962-86-3

Upstream product

• 101279-97-4 4-methyl-3-phenyl-2-phenylimino-thiazolidin-4-ol 
• 622-16-2 1,3-Diphenylcarbodiimide 
• 24653-75-6 1-mercaptopropan-2-one 
• 78-95-5 chloroacetone 
• 102-08-9 N,N-diphenylthiourea 
• 67-64-1 acetone 
• 103-72-0 phenyl isothiocyanate 
• 62-53-3 aniline 
• 127040-71-5 [4-Iodomethyl-3-phenyl-thiazolidin-(2Z)-ylidene]-phenyl-amine 
• 598-31-2 1-bromoacetone 
• 127040-65-7 2-Allyl-1,3-diphenyl-isothiourea 
• 3898-08-6 1,1-diphenylthiourea 

Downstream Products

• 5316-80-3 4-methyl-3-phenyl-1,3-thiazole-2(3H)-thione 

Relevant academic research and scientific papers

Efficient synthetic procedure to new 2-imino-1,3-thiazolines and thiazolidin-4-ones promoted by acetonitrile electrogenerated base

A novel and convenient strategy is described for the regioselective conversion of N,N′-disubstituted thioureas and 1,2-dielectrophiles into the highly biologically valuable 2-imino-thiazoline and 2-imino thiazolidine-4-one derivatives. The synthesis proce

Multicomponent Synthesis of Uracil Analogues Promoted by Pd-Catalyzed Carbonylation of α-Chloroketones in the Presence of Isocyanates and Amines

A short and efficient one-pot synthesis of uracil derivatives with a high structural variability is described. The process is a multicomponent reaction based on a palladium-catalyzed carbonylation of α-chloroketones in the presence of primary amines and i

A convenient one-pot synthesis of thiazol-2-imines: application in the construction of pifithrin analogues

For the first time a reaction intermediate has been isolated giving further insight into the mechanism of thiazol-2-imine formation. The first step of the reaction requires a basic medium, while the second step is an acid mediated E1 elimination reaction. An efficient one-pot synthesis of substituted thiazol-2-imines have been achieved by the condensation of carbonyl compounds with thioureas and 1,3-disubstituted thioureas using 1,1′-(ethane-1,2-diyl)dipyridinium bistribromide (EDPBT). Unsymmetrical 1,3-disubstituted thioureas give regioselective products with symmetrical ketones, which are mainly governed by the pKas of NH protons of thiourea, whereas symmetrical 1,3-disubstituted thioureas give regioselective products with symmetrical carbonyl compounds owing to the regioselective bromination of ketones. The methodology is extended to access novel neurodegenerative drug candidate pifithrin-α analogues in good yields in shorter reaction time. This method is simple, versatile and is applicable for different 1,3-disubstituted thioureas as well as a range of carbonyl compounds.

SYNTHESIS AND ELABORATION OF HETEROCYCLES VIA IODOCYCLISATION OF UNSATURATED THIOUREAS

Iodocyclisation of N-allyl or S-allyl thioureas leads efficiently to dihydrothiazoles, and dihydroimidazoles and homologous thioureas afford dihydrothiazines.The products are readily elaborated to give unusual heterocyclic systems.