229620-58-0Relevant articles and documents
Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y 1 antagonists
Chao, Hannguang,Turdi, Huji,Herpin, Timothy F.,Roberge, Jacques Y.,Liu, Yalei,Schnur, Dora M.,Poss, Michael A.,Rehfuss, Robert,Hua, Ji,Wu, Qimin,Price, Laura A.,Abell, Lynn M.,Schumacher, William A.,Bostwick, Jeffrey S.,Steinbacher, Thomas E.,Stewart, Anne B.,Ogletree, Martin L.,Huang, Christine S.,Chang, Ming,Cacace, Angela M.,Arcuri, Maredith J.,Celani, Deborah,Wexler, Ruth R.,Lawrence, R. Michael
, p. 1704 - 1714 (2013/04/10)
Two distinct G protein-coupled purinergic receptors, P2Y1 and P2Y12, mediate ADP-driven platelet activation. The clinical effectiveness of P2Y12 blockade is well established. Recent preclinical data suggest that P2Y1
Kinetics of the reaction of 2-chloro-3-nitro- and 2-chloro-5-nitropyridines with aryloxide ions in methanol
El-Bardan, Ali A.
, p. 347 - 353 (2007/10/03)
The kinetics of the reaction of 2-chloro-3-nitropyridine (ortho-like) and 2-chloro-5-nitropyridine (para-like) with a series of aryloxide ions were studied in methanol at different temperatures. Plots of ΔH* versus ΔS* for both reactions gave good straight lines with isokinetic temperatures of 168 and 195°C. Good linear relationships were obtained from the plots of log k2 against σ° values with relatively large negative ρ values indicating the formation of Meisenheimer σ-complex intermediates. Plots of log k2 against pKa values gave good straight lines indicating that the reactions show an appreciable degree of bond formation in the transition state. An addition-elimination mechanism is suggested. Copyright
