22984-73-2

Upstream product

• 70-11-1 α-bromoacetophenone 
• 105-34-0 methyl 2-cyanoacetate 
• 124-41-4 sodium methylate 
• 532-27-4 1-chloroacetophenone 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 2051-95-8 succinylbenzene 
• 1189516-84-4 C₁₅H₁₅NO₂ 
• 1189516-88-8 C₁₇H₁₉NO₂ 
• 1190846-18-4 C₁₅H₁₄INO₃ 
• 848244-03-1 methyl 2-chloro-5-phenyl-1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

Diastereoselective synthesis of polysubstituted cyclopentanols and cyclopentenes containing stereogenic centers via domino Michael/cyclization reaction

A highly efficient domino Michael/cyclization reaction was developed for the synthesis of cyclopentanols and cyclopentenes with four and three stereogenic centers that were generated in one-pot reaction conditions with high diastereoselectivity. The reactions proceeded through a one-pot three-component reaction of β-nitrostyrenes, malononitrile and phenacyl bromide derivatives in basic media at room temperature.

Novel Platensimycin Derivatives, Their Intermediates, and Process for Preparing the Same, and New Process for Preparing Platensimycin

The present invention relates to novel platensimycin derivatives, their intermediates and preparing methods of the same. Platensimycin is known as an effective antibiotic material having a broad antimicrobial spectrum and its derivatives are also expected to be effective antibiotic candidates. The present invention also relates to a novel preparing method of platensimycin. The intermediates used for the production of platensimycin and its derivatives of the present invention are tricyclo ketone derivatives and tetracyclo derivatives. Tetracyclo derivatives are prepared from tricyclo ketone derivatives prepared by carbonyl ylide [3+2] cycloaddition of dia-zoketone derivative.

7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: More potent analogs of platensimycin

Carbonyl ylide cycloaddition strategy was employed in the synthesis of platensimycin analogs. 7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin are more potent analogs of platensimycin.

NOVEL PLATENSIMYCIN DERIVATIVES, THEIR INTERMEDIATES, AND PROCESS FOR PREPARARING THE SAME, AND NEW PROCESS FOR PREPARING PLATENSIMYCIN

The present invention relates to novel platensimycin derivatives, their intermediates and preparing methods of the same. Platensimycin is known as an effective antibiotic material having a broad antimicrobial spectrum and its derivatives are also expected to be effective antibiotic candidates. The present invention also relates to a novel preparing method of platensimycin. The intermediates used for the production of platensimycin and its derivatives of the present invention are tricyclo ketone derivatives and tetracyclo derivatives. Tetracyclo derivatives are prepared from tricyclo ketone derivatives prepared by carbonyl ylide [3+2] cycloaddition of dia- zoketone derivative

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

THIENOPYRROLES AS ANTIVIRAL AGENTS

The present invention relates to thienopyrrole compounds of formula (I); wherein A, B, Y, Ar, n, Z and X1 are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.