229976-40-3Relevant academic research and scientific papers
Efficient asymmetric synthesis of the vasopeptidase inhibitor BMS-189921
Singh, Janak,Kronenthal, David R.,Schwinden, Mark,Godfrey, Jollie D.,Fox, Rita,Vawter, Edward J.,Zhang, Bo,Kissick, Thomas P.,Patel, Bharat,Mneimne, Omar,Humora, Michael,Papaioannou, Chris G.,Szymanski, Walter,Wong, Michael K. Y.,Chen, Chien K.,Heikes, James E.,DiMarco, John D.,Qiu, Jun,Deshpande, Rajendra P.,Gougoutas, Jack Z.,Mueller, Richard H.
, p. 3155 - 3158 (2007/10/03)
(Matrix presented) An efficient asymmetric synthesis of the vasopeptidase inhibitor BMS-189921 was accomplished. Two short enantioselective syntheses of the common key intermediate (S)-α-aminoazepinone 6b were developed. Olefin 3 was converted to 6b via a
Deprotection and recrystallization processes
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Example 5, (2008/06/13)
Acylmercaptoalkanoylamino lactam esters or acids are converted to the corresponding mercaptoalkanoylamino lactam ester or acid under basic conditions by including an agent which minimizes the amount of disulfides. Suitable agents are bismercaptans, phosphine or phosphite reducing agents, zinc metal powder, and sodium hydrosulfite. Such agents are also employed in the recrystallization and reprocessing of the mercaptoalkanoylamino lactam acids.
