76932-17-7

Usage

Chemical Properties

White Solid

Upstream product

• 42990-55-6 (S)-(alpha)-bromobenzenepropanoic acid 
• 10387-40-3 potassium thioacetate 
• 507-09-5 tiolacetic acid 
• 29632-72-2 (R)-thioacetate 
• 20312-36-1 L-3-phenyllactic acid 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 100-44-7 benzyl chloride 
• 101308-40-1 ethyl 2-bromo-3-phenylpropionate 
• 673-06-3 D-(R)-phenylalanine 
• 63-91-2 L-phenylalanine 
• 56827-86-2 cesium thioacetate 
• 7474-06-8 (2R)-2-chloro-3-phenylpropionic acid 
• 496962-20-0 ethyl 2-acetylthio-3-benzenepropanoate 
• 34832-35-4 sodium thioacetate 

Downstream Products

• 785748-27-8 (R)-2-((S)-1-Carboxy-2-phenyl-ethylsulfanyl)-3-phenyl-propionic acid 
• 177741-93-4 (2S,5R)-1-[2-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-acetyl]-5-phenyl-pyrrolidine-2-carboxylic acid methyl ester 
• 177742-01-7 (2S,5R)-1-[2-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-acetyl]-5-(3-hydroxy-phenyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 177742-03-9 (2S,5R)-1-[2-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-acetyl]-5-m-tolyl-pyrrolidine-2-carboxylic acid ethyl ester 
• 177742-00-6 (2S,5R)-1-[2-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-acetyl]-5-(2-hydroxy-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 177742-02-8 (2S,5R)-1-[2-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-acetyl]-5-o-tolyl-pyrrolidine-2-carboxylic acid ethyl ester 
• 177930-62-0 (2S,5S)-1-[2-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-acetyl]-5-o-tolyl-pyrrolidine-2-carboxylic acid ethyl ester 
• 632297-58-6 methyl N-{(2S)-2-[(acetylthio)methyl]-3-phenylpropanoyl}-4-(1H-pyrazol-1-yl)-L-phenylalaninate 
• 160135-05-7 [3S-[3α(R*),7β]]-7-(Cyclopentyl)hexahydro-3-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]-2-oxo-1H-azepine-1-acetic acid, methyl ester 
• 160135-02-4 [(3S,7R)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-7-cyclopropylmethyl-2-oxo-azepan-1-yl]-acetic acid methyl ester 
• 1027542-31-9 (S)-2-[(3S,7S)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-2-oxo-7-propyl-azepan-1-yl]-butyric acid methyl ester 
• 160135-35-3 [(3S,7R)-3-((S)-2-Acetylsulfanyl-3-phenyl-propionylamino)-7-(2-hydroxy-ethyl)-2-oxo-azepan-1-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use

The present invention relates to ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate], the preparation of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylenediamine in 2-propanol, and the use of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] for the preparation of ACE/NEP inhibitors.

Crystallization-induced chiral inversion as the key step for synthesis of (S)-2-acetylthio-3-phenylpropanoic acid from L-phenylalanine

(Chemical Equation Presented) A novel crystallization-induced chiral inversion of (S)-2-bromo-3-phenylpropanoic acid to its (R)-enantiomer with excellent enantiomeric excess (96-99%) is achieved. Optically pure (S)-2-acetylthio-3-phenylpropanoic acid can

Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes

Twenty one chromogenic thiopeptolide substrates were designed and synthesized as the active site probes and analyzed with each S1 site of mutant residues and enzymes of wild-type MetAP1s. The preliminary enzymatic experiments indicate that cysteine 70 or 202, at either Escherichia coli or human MetAP1, played a crucial role in the methionine hydrolysis.

PROCESS FOR PREPARING 2-ACETYLTHIO-3-PHENYL-PROPIONIC ACID AND THE SALTS THEREOF

It is described a process for preparing 2-acetylthio-3-phenyl-propionic acid and the salts thereof starting from 2-bromo-3-phenyl-propionic acid and potassium thioacetate in an organic solvent and in the presence of a phase transfer catalyst.

Synthesis of optically pure (S)-2-acetylthio-3-benzenepropanoic acid via enzymatic resolution

A method of synthesizing optically pure (S)-2-acetylthio-3-benzenepropanoic acid has been developed and good to excellent enantiomeric excess achieved via enzymatic resolution.

Dynamic resolution of isomers and resolved isomers

Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, wherein the alpha sub

Synthesis and Biological Activity of Hydroxamic Acid-Derived Vasopeptidase Inhibitor Analogues

(Equation Presented) Syntheses of novel hydroxamic acid-derived azepinones containing pendant mercaptoacyl groups or formyl hydroxamates are described. These new analogues of therapeutically important ACE and NEP inhibitors include unprecedented changes a

Process for preparing 2-acetythio-3-phenyl-propionic acid and the salts thereof

It is described a process for preparing 2-acetylthio-3-phenyl-propionic acid and the salts thereof starting from 2-bromo-3-phenyl-propionic acid and potassium thioacetate in an organic solvent and in the presence of a phase transfer catalyst.

Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-β-lactamase

Potent thioester and thiol inhibitors of IMP-1 metallo-β-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step.

AMINO ACID DERIVATIVE

The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibition activity.This amino acid derivative is represented by the following general formula (I): STR1 wherein R 1 represents a hydrogen atom or an acyl group; R 2 represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, an ary group which may have a substituent, a heteroaryl group which may have a substituent, an arylalkyl group which may have a substituent or a heteroarylalkyl group which may have a substituent;m and n represent each independently an integer of 0, 1 or 2 and J represents a cyclic group having an angiotensin I-converting enzyme inhibition activity.