230-46-6

Basic information

• Product Name: 1,7-Phenanthroline
• Synonyms: AKOS 90061;1,7-PHENANTHROLINE;PHENANTHROLINE;M-PHENANTHROLINE;1,5-Diazaphenanthrene;4,10-Phenanthroline;NSC 35679;Pyrido[2,3-f]quinoline
• CAS NO: 230-46-6
• Molecular Formula: C₁₂H₈N₂
• Molecular Weight: 180.2053
• EINECS: 205-936-5
• Product Categories: Heterocyclic Building Blocks;N-Containing;Others
• Mol File: 230-46-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 79-81℃
• Boiling Point: 365.1 °C at 760 mmHg
• Flash Point: 164.8 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 3.38E-05mmHg at 25°C
• Refractive Index: 1.74
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: pK1:4.30(+1) (25°C)
• Water Solubility: It is soluble in water, ethanol, ether and benzene.
• CAS DataBase Reference: 1,7-Phenanthroline(CAS DataBase Reference)
• NIST Chemistry Reference: 1,7-Phenanthroline(230-46-6)
• EPA Substance Registry System: 1,7-Phenanthroline(230-46-6)

Safety Data

• Hazard Codes: Xn,N,T
• Statements: 22-41-50/53-25
• Safety Statements: 26-36/39-61-60-45-39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: SF8290000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 230-46-6(Hazardous Substances Data)

Usage

Uses

1,7-Phenanthroline acts as an inhibitor of germination and growth of plants. it can be used to produce [1,7]phenanthroline-8-carbonitrile with hydrocyanic acid; potassium salt at temperature. It is also used as an intermediate and chemical research.

General Description

1,7-Phenanthroline has inhibitory effect on germination and growth of plants. 1,7-Phenanthroline is an aza-analog of phenanthrene, was found to be mutagenic in the Ames test using Salmonella typhimurium TA100 in the presence of a rat liver S9 fraction. Supramolecular assemblies of 1,2,4,5-benzenetetracarboxylic acid with 1,7-phenanthroline (aza donor molecule) were investigated.

InChI:InChI=1/C12H8N2/c1-3-9-5-6-11-10(4-2-7-13-11)12(9)14-8-1/h1-8H

Upstream product

• 56-81-5 glycerol 
• 99-09-2 3-nitro-aniline 
• 7647-01-0 hydrogenchloride 
• 613-51-4 7-nitroquinoline 
• 76795-62-5 7-ethoxycarbonyl-7,8-dihydro-1,7-phenanthroline-8-carbonitrile 
• 108-45-2 m-phenylenediamine 
• 611-34-7 5-Aminoquinoline 

Downstream Products

• 780790-76-3 C₂₄H₁₆N₂O₃ 
• 76795-60-3 7-benzoyl-8-cyano-10-methyl-7,10-dihydro-1,7-phenanthroline 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 

Related news

In vivo mutagenicity of benzo[f]quinoline, benzo[h]quinoline, and 1,7-Phenanthroline (cas 230-46-6) using the lacZ transgenic mice09/30/2019

Phenanthrene, a simplest angular polycyclic aromatic hydrocarbon with a bay-region in its molecule, is reported to be non-mutagenic, although most angular (non-linear) polycyclic aromatic hydrocarbons, such as benzo[a]pyrene and chrysene, are known to show genotoxicity after metabolic transforma...detailed

Barbituric acid in the synthesis of fused 1,7-Phenanthroline (cas 230-46-6) derivatives09/29/2019

New 7-aryl(hetaryl)-7,8,9,10,11,12-hexahydropyrimido[5,4-b][1,7]phenanthroline-9,11-diones have been synthesized by three-component condensation of barbituric acid with quinolin-5-amine and aromatic or heteroaromatic aldehydes.detailed

Aldehydes of furan series in the synthesis of 1,7-Phenanthroline (cas 230-46-6) derivatives09/28/2019

By condensation of quinolin-5-amine with 5-arylfuran-2-carbaldehydes and cyclohexane-1,3-dione or dimedone new compounds were synthesized, 10,10-dimethyl-7-(5-arylfuran-2-yl)-9,10,11,12-tetrahydrobenzo[b][1,7]phenanthrolin-8(7H)-ones unsubstituted in the position 10.detailed

Relevant articles and documents

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Heteroannulation of 3-Bis(methylthio)acrolein with Aromatic Amines - A Convenient Highly Regioselective Synthesis of 2-(Methylthio)quinolines and their Benzo/Hetero Fused Analogs: A Modified Skraup Quinoline Synthesis

A simple and efficient synthesis of 2-(methylthio)quinolines and their condensed analogs has been developed through acid-induced cyclocondensation of their respective anilines or aromatic diamines with 3-bis(methylthio)acrolein. The 2-(methylthio) functionality in these quinolines could be either dethiomethylated or replaced by various nitrogen and carbon nucleophiles to afford 2-substituted quinolines.

Some Reactions of N-Alkoxycarbonyl Reissert Compounds with Heterocumulenes: Formation of the Imidazoisoquinoline and Imidazophthalazine Systems and Related Chemistry

Chloroformate derived Reissert compounds of isoquinoline and of phenanthridine on treatment with base undergo cyclisation with isothiocyanates to give in good yields corresponding imidazoisoquinoline and imidazophenanthroline derivatives.Phthalazine Reissert compound analogues give open chain adducts under the same conditions which can be cyclised to derivatives of the novel imidazophthalazine system by heating in the presence of molecular sieves.When carbon disulphide is the heterocumulene cyclisation is not observed but open chain dithio-ester derivatives can be isolated on alkylation of the intermediate sodium salts.