2300-03-0 Usage
Uses
Used in Pharmaceutical Industry:
6α-Fluoropregn-4-ene-3,20-dione is used as a key intermediate in the synthesis of corticosteroids such as flumethasone and halopredone acetate. These corticosteroids leverage the anti-inflammatory and immunosuppressive properties of 6α-Fluoropregn-4-ene-3,20-dione for the treatment of various inflammatory and allergic conditions.
Used in Drug Development:
6α-Fluoropregn-4-ene-3,20-dione serves as a promising candidate for the development of new pharmaceuticals targeting inflammatory and allergic diseases. Its enhanced potency and duration of action, attributed to the fluorine atom at the 6α position, make it an attractive molecule for creating more effective treatments in this therapeutic area.
Check Digit Verification of cas no
The CAS Registry Mumber 2300-03-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,0 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2300-03:
(6*2)+(5*3)+(4*0)+(3*0)+(2*0)+(1*3)=30
30 % 10 = 0
So 2300-03-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H29FO2/c1-12(23)15-4-5-16-14-11-19(22)18-10-13(24)6-8-21(18,3)17(14)7-9-20(15,16)2/h10,14-17,19H,4-9,11H2,1-3H3/t14-,15+,16-,17-,19-,20+,21+/m0/s1
2300-03-0Relevant articles and documents
Kinetics of Electrophilic Fluorination of Steroids and Epimerisation of Fluorosteroids
Rozatian, Neshat,Harsanyi, Antal,Murray, Ben J.,Hampton, Alexander S.,Chin, Emily J.,Cook, Alexander S.,Hodgson, David R. W.,Sandford, Graham
, p. 12027 - 12035 (2020/08/28)
Fluorinated steroids, which are synthesised by electrophilic fluorination, form a significant proportion of marketed pharmaceuticals. To gain quantitative information on fluorination at the 6-position of steroids, kinetics studies were conducted on enol ester derivatives of progesterone, testosterone, cholestenone and hydrocortisone with a series of electrophilic N?F reagents. The stereoselectivities of fluorination reactions of progesterone enol acetate and the kinetic effects of additives, including methanol and water, were investigated. The kinetics of epimerisation of 6β-fluoroprogesterone to the more pharmacologically active 6α-fluoroprogesterone isomer in HCl/acetic acid solutions are detailed.
