23000-15-9Relevant articles and documents
Design, synthesis and X-ray structure of protein-ligand complexes: Important insight into selectivity of memapsin 2 (β-secretase) inhibitors
Ghosti, Arun K.,Kumaragurubaran, Nagaswamy,Hong, Lin,Lei, Hui,Hussain, Khaja Azhar,Liu, Chun-Feng,Devasamudram, Thippeswamy,Weerasena, Vajira,Turner, Robert,Koelsch, Gerald,Bilcer, Geoffrey,Tang, Jordan
, p. 5310 - 5311 (2006)
Structure-based design, synthesis, and X-ray structure of protein-ligand complexes of memapsin 2 are described. The inhibitors are designed specifically to interact with S2- and S3-active site residues to provide selectivity over mem
CpRu-catalyzed O-H insertion and condensation reactions of α-diazocarbonyl compounds
Austeri, Martina,Rix, Diane,Zeghida, Walid,Lacour, Jerome
supporting information; experimental part, p. 1394 - 1397 (2011/05/03)
[CpRu(CH3CN)3][PF6] and diimine ligands catalyze together the decomposition of α-diazocarbonyl compounds leading to O-H insertion and condensation reactions. In comparison with Rh(II) and Cu(I) complexes, the CpRu catalysts produce rapid and often more selective reactions. Promising enantioselectivities are obtained in dioxole syntheses.
Expeditious syntheses of conjugated allenyl esters and oxazoles through a cascade reaction of α-alkynyl malonates under alkaline conditions
Sano, Shigeki,Shimizu, Hisashi,Kim, Kweon,Lee, Woo Song,Shiro, Motoo,Nagao, Yoshimitsu
, p. 196 - 203 (2007/10/03)
Diethyl α-alkynyl-α-methoxymalonates (2a-e) were smoothly hydrolyzed and then decarboxylated under alkaline conditions employing 1 N KOH in EtOH to give conjugated allenyl esters (6a-e) in high yields, and similar alkaline treatment of diethyl α-alkynyl-α
Chemistry of 5-oxodihydroisoxazoles. Part 18. Synthesis of oxazoles by the photolysis and pyrolysis of 2-acyl-5-oxo-2,5-dihydroisoxazoles
Prager, Rolf H.,Smith, Jason A.,Weber, Ben,Williams, Craig M.
, p. 2665 - 2672 (2007/10/03)
N-Acylisoxazol-5-ones lose carbon dioxide under photochemical and thermal conditions affording iminocarbenes which undergo intramolecular cyclisation through the oxygen of the acyl group to give oxazoles. Under photochemical conditions those acylisoxazolones with electron withdrawing groups at C-4 usually give high yields of oxazoles, while those with electron donating groups at C-4 give only poor yields: the reverse is observed under thermal conditions.
The synthesis of oxazoles by thermolysis or photolysis of 2-acylisoxazol-5-ones
Ang, Kiah H.,Prager, Rolf H.,Smith, Jason A.,Weber, Ben,Williams, Craig M.
, p. 675 - 678 (2007/10/02)
N-acylisoxazol-5-ones are converted into the corresponding 2-substituted oxazoles by photolysis at 300 or 254 nm, or by flash vacuum pyrolysis. The former procedure is favoured for isoxazolones with electron withdrawing groups at C-4, and pyrolysis for all others.
Amino Acids, 2. N-Acetyl α,β-Didehydro α-Amino Acid Esters from α-Azidocarboxylic Acid Esters and Acetic Anhydride by Nitrogen Elimination with Rhenium Catalysts
Effenberger, Franz,Beisswenger, Thomas
, p. 1497 - 1512 (2007/10/02)
α-Azidocarboxylic acid esters 2 react with acetic anhydride in presence of catalytic amounts of rhenium heptasulfide and - if necessary - by addition of hydrochloric acid to give N-acetyl 3 or/and N,N-diacetyl-α,β-didehydro-α-amino acid esters 4 in very g
