92901-94-5

Basic information

• Product Name: (2,5-DIMETHYL-1,3-OXAZOL-4-YL)METHANOL
• Synonyms: (2,5-DIMETHYL-1,3-OXAZOL-4-YL)METHANOL;(2,5-Dimethyl-1,3-oxazol-4-yl)methanol 97%;2,5-Dimethyl-4-(hydroxymethyl)-1,3-oxazole;(2,5-Dimethyloxazol-4-yl)methanol;2,5-Dimethyl-4-(hydroxymethyl)-1,3-oxazole 97%;2,5-Dimethyl-4-(hydroxymethyl)-1,3-oxazole97%
• CAS NO: 92901-94-5
• Molecular Formula: C₆H₉NO₂
• Molecular Weight: 127.14
• EINECS: 200-258-5
• Mol File: 92901-94-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 73 °C
• Boiling Point: 222.012 °C at 760 mmHg
• Flash Point: 88.07 °C
• Appearance: /
• Density: 1.137 g/cm³
• Vapor Pressure: 0.06mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: 2-8°C
• PKA: 13.15±0.10(Predicted)
• CAS DataBase Reference: (2,5-DIMETHYL-1,3-OXAZOL-4-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2,5-DIMETHYL-1,3-OXAZOL-4-YL)METHANOL(92901-94-5)
• EPA Substance Registry System: (2,5-DIMETHYL-1,3-OXAZOL-4-YL)METHANOL(92901-94-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 92901-94-5(Hazardous Substances Data)

Usage

General Description

(2,5-Dimethyl-1,3-oxazol-4-yl)methanol is a chemical compound belonging to the class of organic compounds known as oxazoles, characterized by an oxazol ring, a five-membered aromatic ring featuring an oxygen atom and a nitrogen atom. Its specific structure consists of a 1,3-oxazol-4-yl methanol that carries two methyl substituents in the 2 and 5 positions of the oxazole ring. Given its molecular formula, it can be deduced that this compound involves a mix of carbon, hydrogen, nitrogen, and oxygen atoms. It is less commonly found in the commercial or industrial setting, thus its uses and potential hazards may not be comprehensively reviewed or detailed. The potential toxicity or other physical and chemical properties of such a compound require thorough investigation on its exposure effects. It is advisable to handle with care following reasonable protective measures.

InChI:InChI=1/C6H9NO2/c1-4-6(3-8)7-5(2)9-4/h8H,3H2,1-2H3

Upstream product

• 23000-14-8 2,5-dimethyl-1,3-oxazole-4-carboxylic acid 
• 141567-53-5 4-hydroxymethyl-2-methyloxazole 
• 333-27-7 methyl trifluoromethanesulfonate 
• 98432-01-0 methyl 2-acetamido-3-oxobutanoate 
• 5431-93-6 ethyl 2-(acetylamino)-3-oxobutanoate 
• 23000-15-9 2,5-Dimethyl-4-oxazolcarbonsaeure-ethylester 

Downstream Products

• 859850-62-7 2,5-dimethyloxazol-4-ylmethanamine 
• 1026044-87-0 C₁₇H₂₁N₃O₆S 
• 940879-52-7 3-{[(2,5-dimethyloxazol-4-yl)methyl]carbamoyl}-5-(N-methylmethan-5-ylsulfonamido)benzoic acid 
• 1026742-99-3 C₄₀H₆₈N₆O₈SSi 
• 92901-89-8 α-<1-(Ethoxymethyl)-2-(phenylthio)-1H-imidazol-5-yl>-2,5-dimethyl-4-oxazolemethanol 
• 92901-90-1 (2,5-Dimethyl-4-oxazolyl)<1-(ethoxymethyl)-2(phenylthio)-1H-imidazol-5-yl>methanone 

Relevant articles and documents

Synthesis and evaluation of a novel series of 2,7-substituted-6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline derivatives as selective peroxisome proliferator-activated receptor γ partial agonists

A novel series of 7-substituted-2-[3-(2-furyl)acryloyl]-6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized to clarify structure–activity relationships for peroxisome proliferator-activated receptor γ (PPARγ) partial agonist activity

Design, synthesis and X-ray structure of protein-ligand complexes: Important insight into selectivity of memapsin 2 (β-secretase) inhibitors

Structure-based design, synthesis, and X-ray structure of protein-ligand complexes of memapsin 2 are described. The inhibitors are designed specifically to interact with S2- and S3-active site residues to provide selectivity over mem

Selective lithiation of 2-methyloxazoles. Applications to pivotal bond constructions in the phorboxazole nucleus

(equation presented) R = Alkyl, Vinyl, Aryl 6:7 >95:5 The lithiation of 2-methyloxazoles with alkyllithium and hindered lithium amide bases generally results in the competitive formation of a mixture of 5-lithio-and 2-(lithiomethyl)oxazole isomers. Herein a synthetically useful lithiation method which allows for the selective formation of 2-(lithiomethyl)oxazole is described. Diethylamine has been found to be a kinetically competent proton source that will mediate the equilibration of the kinetically formed 5-lithiooxazole to its more stable 2-(lithiomethyl)oxazole counterpart. Application of this metalation strategy with lithium diethylamide to two important bond constructions relevant to a projected phorboxazole synthesis is presented.