23002-62-2

Upstream product

• 4132-48-3 1-methoxy-4-(1-methylethyl)benzene 
• 67-64-1 acetone 
• 104-47-2 p-methoxybenzylnitrile 
• 5351-07-5 2-(4-methoxy-phenyl)-2-methyl-propionitrile 
• 2955-46-6 2-(4-methoxyphenyl)-2-methylpropanoic acid 
• 917-64-6 methyl magnesium iodide 
• 2901-19-1 ethyl 2-(4-methoxyphenyl)-2-methylpropanoate 

Downstream Products

• 19884-70-9 2,3-Dimethyl-3-(4-methoxy-phenyl)-2-chlor-butan 

Relevant academic research and scientific papers

Photocatalytic carbanion generation from C-H bonds-reductant free Barbier/Grignard-type reactions

We report a redox-neutral method for the generation of carbanions from benzylic C-H bonds in a photocatalytic Grignard-type reaction. The combination of photo- and hydrogen atom transfer (HAT) catalysis enables the abstraction of a benzylic hydrogen atom, generating a radical intermediate. This radical is reduced in situ by the organic photocatalyst to a carbanion, which is able to react with electrophiles such as aldehydes or ketones, yielding homobenzylic secondary and tertiary alcohols.