2955-46-6

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Methoxy-α,α-dimethyl-Benzeneacetic acid is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into the molecular structures of different drugs. Its unique chemical structure allows it to contribute to the development of new medications with specific therapeutic effects.
Used in Medicinal Research:
In the field of medicinal research, 4-methoxy-α,α-dimethyl-Benzeneacetic acid is used as a compound of interest for studying its potential properties and applications in medicine. Researchers explore its interactions with biological systems to understand its possible therapeutic benefits and mechanisms of action.
Used in Chemical Industry:
4-Methoxy-α,α-dimethyl-Benzeneacetic acid is also utilized in the chemical industry for various purposes, including the production of specialty chemicals, agrochemicals, and other related products. Its versatility in chemical reactions makes it a valuable component in the synthesis of a wide range of compounds.

InChI:InChI=1/C11H14O3/c1-11(2,10(12)13)8-4-6-9(14-3)7-5-8/h4-7H,1-3H3,(H,12,13)

Upstream product

• 32454-14-1 2-(4-methoxyphenyl)-2-methylpropanal 
• 5351-07-5 2-(4-methoxy-phenyl)-2-methyl-propionitrile 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 74-88-4 methyl iodide 
• 2696-34-6 4-(1,1-dimethyl-pent-4-en-2-ynyl)-anisole 
• 67-64-1 acetone 
• 55770-61-1 2-(4-Hydroxyphenyl)-2-methylpropionitrile 
• 74-83-9 methyl bromide 
• 942-54-1 2-(4-methoxyphenyl)propanoic acid 
• 50415-73-1 methyl 2-(4-methoxyphenyl)propionate 
• 6274-50-6 methyl 2-(4-methoxyphenyl)-2-methylpropanoate 
• 104-01-8 4-Methoxyphenylacetic acid 
• 36025-15-7 2-bromo-1-(4-methoxyphenyl)-2-methylpropan-1-one 
• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 29913-51-7 2-methyl-2-(p-hydroxyphenyl)-propionic acid 
• 1712-69-2 1-isopropenyl-4-methoxybenzene 
• 117081-66-0 Acetic acid 2-hydroxy-2-(4-methoxy-phenyl)-propyl ester 
• 141427-01-2 4-(2'-carboxy-2'-methylpropylmercapto)phenyl 2-(4'-methoxyphenyl)isobutyrate 
• 6274-50-6 methyl 2-(4-methoxyphenyl)-2-methylpropanoate 
• 2778-45-2 1-(2-isocyanatopropan-2-yl)-4-methoxybenzene 
• 32454-14-1 2-(4-methoxyphenyl)-2-methylpropanal 
• 871822-60-5 (2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide 
• 871822-53-6 methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate 

Relevant academic research and scientific papers

Palladium-Catalyzed Distal m-C-H Functionalization of Arylacetic Acid Derivatives

Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol).

EP300/CREBBP INHIBITOR

The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

Cobalt-catalyzed C[sbnd]H activation/C[sbnd]O formation: Synthesis of benzofuranones

Herein, C[sbnd]H activation/C[sbnd]O formation reaction using novel cobalt catalytic system is reported. This reaction was given benzofuranones in moderate to excellent yields at room-temperature under air reaction conditions. The introduced strategy is efficient and low-cost method to synthesized benzofuranones from α,α-disubstitution acetic acid.

Palladium(II)-Catalyzed C(sp2)-H Carbonylation of Sterically Hindered Amines with Carbon Monoxide

A palladium-catalyzed, amine-directed C(sp2)-H carbonylation of α,α-disubstituted benzylamine under 1 atm of CO for the facile synthesis of sterically hindered benzolactam has been developed. The key to success is the use of 2,2,6,6-tetramethyl-1-piperidinyloxy as the crucial sole oxidant. The synthetic utility of this transformation has been demonstrated by the first concise synthesis of the natural product spiropachysin-20-one.

Nickel-Catalyzed oxidative coupling of unactivated C(sp3)-H bonds in aliphatic amides with terminal alkynes

In this work, we demonstrated Ni-catalyzed oxidative coupling of unactivated C(sp3)-H bonds with terminal alkynes for construction of C(sp3)-C(sp) bonds to synthesize alkyl-substituted internal alkynes. Different amides exhibited good compatibility. Preliminary mechanistic studies were conducted to account for this alkynylation.

Amide-Directed C?H Sodiation by a Sodium Hydride/Iodide Composite

A new protocol for amide-directed ortho and lateral C?H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds.

A α - (4 - substituted phenyl) of isobutyric acid preparation method

The invention relates to the field of organic chemical synthesis and discloses a preparation method of alpha-(4-substituted phenyl)isobutyric acid. The method comprises the steps of respectively carrying out Friedel-Crafts acylation, condensation reaction, rearrangement reaction and hydrolytic acidification reaction on single substituted benzene and 2-haloisobutyryl halide or isobutyryl halide serving as an acylating agent to finally prepare a finished product of alpha-(4-substituted phenyl)isobutyric acid. The preparation method provided by the invention has the advantages that the raw materials are easily obtained and are relatively low in toxicity, a catalysis system of the rearrangement reaction can effectively promote the rearrangement reaction, the obtained product is relatively high in purity and yield, the whole preparation method is simple, the adopted reagent is safe, and the preparation method is beneficial to industrial production.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORy.

Direct lactonization of 2-arylacetic acids through Pd(II)-catalyzed C-H activation/C-O formation

Palladium-catalyzed direct lactonization of 2-arylacetic acids through a reaction sequence that includes C-H activation/C-O formation is reported. This method provides a concise and efficient pathway to synthesize fully functionalized benzofuranone derivatives, which are highly relevant to bioactive natural and synthetic products.

Falcipain inhibitors: Optimization studies of the 2-pyrimidinecarbonitrile lead series

Falcipain-2 and falcipain-3 are papain-family cysteine proteases of the malaria parasite Plasmodium falciparum that are responsible for host hemoglobin hydrolysis to provide amino acids for parasite protein synthesis. Different heteroarylnitrile derivatives were studied as potential falcipain inhibitors and therefore potential antiparasitic lead compounds, with the 5-substituted-2- cyanopyrimidine chemical class emerging as the most potent and promising lead series. Through a sequential lead optimization process considering the different positions present in the initial scaffold, nanomolar and subnanomolar inhibitors at falcipains 2 and 3 were identified, with activity against cultured parasites in the micromolar range. Introduction of protonable amines within lead molecules led to marked improvements of up to 1000 times in activity against cultured parasites without noteworthy alterations in other SAR tendencies. Optimized compounds presented enzymatic activities in the picomolar to low nanomolar range and antiparasitic activities in the low nanomolar range.