23019-08-1Relevant articles and documents
C-H Functionalization of Benzothiazoles via Thiazol-2-yl-phosphonium Intermediates
Sch?mberg, Fritz,Vilotijevic, Ivan,Wagner, Konrad,Zi, You
supporting information, (2020/05/05)
Benzothiazoles undergo regioselective C2-H functionalization with triphenylphosphine to form thiazol-2-yl-triphenylphosphonium salts, and these phosphonium salts react with a wide range of O- A nd N-centered nucleophiles to give the corresponding ethers, amines, and C-N biaryls. The reactions proceed under mild conditions and allow for the recovery of triphenylphosphine at the end of the sequence. In the presence of hydroxide, phosphonium salts undergo disproportionation, resulting in the reduction of the benzothiazole, which is useful for specific C2 deuteration of benzothiazoles.
The coupling reactions of aryl halides and phenols catalyzed by palladium and MOP-type ligands
Zhang, Yi,Ni, Gang,Li, Chengjun,Xu, Sheng,Zhang, Zhaoguo,Xie, Xiaomin
, p. 4927 - 4932 (2015/06/23)
Palladium-catalyzed coupling reactions of aryl halides and phenols are described employing the bulky and electron-rich MOP-type ligands. When K3PO4 was used as base and toluene as solvent, the catalyst system exhibited high efficiency for the coupling reaction of the activated aryl halides. When NaH was used as base and o-xylene as solvent, unactivated aryl halides can be used as substrates.
(2-Pyridyl)acetone-promoted Cu-catalyzed O-arylation of phenols with aryl iodides, bromides, and chlorides
Zhang, Qi,Wang, Deping,Wang, Xianyang,Ding, Ke
supporting information; experimental part, p. 7187 - 7190 (2009/12/09)
(Chemical Equation Presented) Employing (2-pyridyl)acetone as a new supporting ligand, the copper-catalyzed coupling reactions of aryl chlorides, aryl bromides, and aryl iodides with various phenols successfully proceeded in good yields under mild conditions. This reaction displays great functional groups compatibility and excellent reactive selectivity.
