23027-90-9

Basic information

• Product Name: 3-methyl-3-phenylisoindolin-1-one
• Synonyms: 3-methyl-3-phenylisoindolin-1-one
• CAS NO: 23027-90-9
• Molecular Weight: 223.274
• Mol File: 23027-90-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-methyl-3-phenylisoindolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-3-phenylisoindolin-1-one(23027-90-9)
• EPA Substance Registry System: 3-methyl-3-phenylisoindolin-1-one(23027-90-9)

Safety Data

• Hazardous Substances Data: 23027-90-9(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 61650-22-4 N-(pivaloyloxy)benzamide 
• 13466-30-3 (1-phenylethylidene)hydrazine 
• 842121-02-2 C₁₂H₁₇NOS 
• 7154-66-7 2-bromobenzoic acid chloride 

Relevant articles and documents

Exploiting the Bis-Nucleophilicity of α-Aminoboronates: Copper-Catalyzed, Intramolecular Aminoalkylations of Bromobenzoyl Chlorides

α-Aminoboronate salts are interesting examples of heteroatomic species containing adjacent nucleophilic centers. We have developed an acylation/arylation reaction using 2-bromobenzoyl chlorides as bis-electrophiles that harnesses the nucleophilicity of both positions, leading to isoindolinones. The reactions proceed under mild conditions via an intramolecular, Cu-catalyzed sp3-sp2 coupling, giving products in up to 95% yield. These conditions enable arylation of α,α-disubstituted aminoboronates, which are difficult to accomplish using methods based on less abundant and more expensive transition metals.