23031-78-9

Basic information

• Product Name: 1,2-Benzisothiazol-3-amine
• Synonyms: 3-AMINOBENZO(2,1)ISOTHIAZOLE;1,2-benzisothiazol-3-amine;3-AMINO-1,2-BENZISOTHIAZOLE;3-AMINOBENZ(2,1)ISOTHIAZOLE;1,2-Benzisothiazol-3-amine(9CI);1,2-Benzisothiazol-3-ylamine;1,2-Benzisothiazol-3-amine Benzo[d]isothiazol-3-ylamine;Einecs 245-388-4
• CAS NO: 23031-78-9
• Molecular Formula: C₇H₆N₂S
• Molecular Weight: 150.2
• EINECS: 245-388-4
• Product Categories: AMINEPRIMARY
• Mol File: 23031-78-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 114 °C(Solv: methanol (67-56-1))
• Boiling Point: 217.591 °C at 760 mmHg
• Flash Point: 85.396 °C
• Appearance: /
• Density: 1.384 g/cm³
• Vapor Pressure: 0.132mmHg at 25°C
• Refractive Index: 1.763
• Storage Temp.: 2-8°C(protect from light)
• PKA: 6.49±0.50(Predicted)
• CAS DataBase Reference: 1,2-Benzisothiazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisothiazol-3-amine(23031-78-9)
• EPA Substance Registry System: 1,2-Benzisothiazol-3-amine(23031-78-9)

Safety Data

• Hazardous Substances Data: 23031-78-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H6N2S/c8-7-5-3-1-2-4-6(5)10-9-7/h1-4H,(H2,8,9)

Upstream product

• 29109-77-1 3-acetamido-1,2-benzisothiazole 
• 7716-66-7 3-chloro-1,2-benzisothiazole 
• 19331-28-3 N-benzo[1,2]dithiol-3-ylidene-acetamide 
• 18637-02-0 2-chlorobenzene-1-carboximidamide hydrogenchloride 
• 873-32-5 2-Chlorobenzonitrile 
• 91589-24-1 o-Chlor-benzaldehyd-imin 
• 45743-05-3 2-chlorobenzimidamide 

Downstream Products

• 104121-42-8 1-(1,2-benzisothiazol-3-yl)urea 
• 104121-54-2 1,2-benzisotiazol-3-ilcarbammato di etile 
• 104121-50-8 1-Benzo[d]isothiazol-3-yl-3-(4-chloro-phenyl)-urea 
• 142503-56-8 C₁₅H₁₃N₃O₃S₂ 
• 69504-36-5 1-Benzo[d]isothiazol-3-yl-3-phenyl-urea 
• 69504-29-6 2-chloro-N-benzo[d]isothiazol-3-yl acetamide 
• 87650-42-8 2-phenylimidazo<1,2-b><1,2>benzisothiazole hydrobromide 
• 142503-58-0 N-Benzo[d]isothiazol-3-yl-benzenesulfonamide 
• 142503-62-6 N-Benzo[d]isothiazol-3-yl-4-methoxy-benzenesulfonamide 
• 104121-49-5 1-Benzo[d]isothiazol-3-yl-3-(3-chloro-phenyl)-urea 
• 142503-54-6 N-(1,2-benzisothiazol-3-yl)-N'-benzenesulfonylurea 
• 142503-46-6 N-(1,2-benzisothiazol-3-yl)-p-acetamidobenzenesulphonamide 
• 104121-51-9 1-Benzo[d]isothiazol-3-yl-3-(3-methoxy-phenyl)-urea 
• 80946-04-9 2-Mercapto-benzamidin 

Relevant articles and documents

Benzisothiazole hypoxia-inducible factor 2 agonist compound or pharmaceutically acceptable salt, preparation method and application thereof

The invention discloses a benzisothiazole hypoxia-inducible factor 2 agonist compound or a pharmaceutically acceptable salt thereof, the compound can stimulate the transcriptional activity of a hypoxia-inducible factor 2 and enhance the generation and secretion of erythropoietin so as to promote the generation of erythrocytes; the prepared benzisothiazole hypoxia-inducible factor 2 agonist compound or the pharmaceutically acceptable salt thereof can be combined with a prolyl hydroxylase inhibitor to play a synergistic role in improving the transcriptional activity of HIF-2, and can be used for treating hypoxia-inducible factor 2 related diseases, such as ischemic diseases and the like.

Efficient synthesis of 1,2-benzisothiazoles from: O -haloarylamidines and elemental sulfur via N-S/C-S bond formation under transition-metal-free conditions

An efficient method for the synthesis of 1,2-benzisothiazoles from amidines and elemental sulfur via N-S/C-S bond formation under transition-metal-free conditions is described. This reaction is performed smoothly under simple conditions to give the corresponding products in good to high yields with good functional group tolerance.