23062-42-2Relevant academic research and scientific papers
Catalyst-Controlled Regiodivergent Dehydrogenative Heck Reaction of 4-Arylthiophene/Furan-3-Carboxylates
Gao, Shang,Wu, Zijun,Wu, Fei,Lin, Aijun,Yao, Hequan
supporting information, p. 4129 - 4135 (2016/12/30)
A catalyst-controlled regiodivergent dehydrogenative Heck reaction of 4-arylthiophene/furan-3-carboxylates has been realized. Use of a palladium catalyst led to the C-5 alkenylation through electronic palladation, while a ruthenium catalyst favored the C-2 alkenylation with the assistance of a directing group. This reaction exhibited good to excellent regioselectivities. (Figure presented.).
Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists
Nagashima, Shinya,Matsushima, Yuji,Hamaguchi, Hisao,Nagata, Hiroshi,Kontani, Toru,Moritomo, Ayako,Koshika, Tadatsura,Takeuchi, Makoto
, p. 3478 - 3487 (2014/06/23)
Herein, we describe the synthesis and pharmacological profiles of novel quinuclidinyl heteroarylcarbamate derivatives. Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagonist (LAMA) showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action in a rat model than tiotropium bromide.
Photochemical generation of thiophene analogs of 9-fluorenyl cations
Bancerz, Mathew,Huck, Lawrence A.,Leigh, William J.,Mladenova, Gabriela,Najafian, Katayoun,Zeng, Xiaofeng,Lee-Ruff, Edward
, p. 1202 - 1213 (2011/09/12)
The 9-fluorenyl cation is a member of the 4N Hueckel antiaromatic series of intermediates, first observed by time-resolved spectroscopy on UV photo-excitation of 9-fluorenol. Thiophene analogs of 9-fluorenol in which one of the annelated benzene rings is
COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
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Page/Page column 113, (2009/07/17)
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combinatio
