23062-91-1

Usage

Uses

PD 102807 is a selective mAChR M4 antagonist.

Biological Activity

Selective M 4 muscarinic receptor antagonist. IC 50 values are 91, 6559, 3441, 950 and 7412 nM for human M 4 , M 1 , M 2 , M 3 , and M 5 receptors respectively.

Upstream product

• 14446-29-8 6-Methoxy-3,4-dihydroisoquinoline 
• 13098-13-0 4-dimethylaminomethyl-5-hydroxy-2-methyl-indole-3-carboxylic acid ethyl ester 
• 110339-54-3 N-[2-(3-methoxy-phenyl)-ethyl]-formamide 
• 626-34-6 ethyl aminocrotonate 
• 106-51-4 p-benzoquinone 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 7598-91-6 ethyl 5-hydroxy-2-methylindole-3-carboxylate 

Relevant academic research and scientific papers

MUSCARINIC ACETYLCHOLINE RECEPTOR SUBTYPE 4 ANTAGONISTS IN THE TREATMENT OF ANEMIA

This disclosure generally relates to treating anemias. More specifically, the disclosure relates to use of muscarinic acetylcholine receptor subtype 4 antagonists, such as small molecule compounds, to promote self-renewal of burst forming unit erythroid (BFU-E) cells and treat anemias.

Identification and characterization of m4 selective muscarinic antagonists

Our interest in the area of m4 muscarinic antagonists has led us to study a series of benzoxazine isoquinolines. One of the most potent and selective compounds of this series is example 1 with an IC50 value of 90.7nM at m4 receptors, and 72-fold (m1), 38-fold (m2), 10-fold (m3), and 82- fold (m5) more selective compared to the other receptors. The synthesis and receptor binding affinity of analogs of 1 are reported.