23112-59-6

Upstream product

• 122-39-4 diphenylamine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 1479-24-9 ethyl 2-fluorobenzoylacetate 
• 122-51-0 orthoformic acid triethyl ester 
• 62-53-3 aniline 
• 393-52-2 2-Fluorobenzoyl chloride 
• 1071-46-1 hydrogen ethyl malonate 
• 23112-58-5 diethyl 2-((diphenylamino)methylene)malonate 

Downstream Products

• 23112-60-9 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid 
• 40695-01-0 1-phenyl-1,4-dihydroquinolin-4-one 
• 325169-36-6 1-phenyl-4-thioxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Method for efficiently and environmentally friendly preparing quinolones

The invention discloses a method for efficiently and environmentally friendly preparing quinolones. Fluorobenzoylacetic acid ethyl ester, triethyl orthoformate and amine compounds are used as raw materials, and the quinolones are synthesized by maintainin

Ethyl 1,4-dihydro-4-oxo-3-quinolinecarboxylates by a tandem addition-elimination-SNAr reaction

The ethyl 1,4-dihydro-4-oxo-3-quinolinecarboxylate ring structure, important in several drug compounds, has been prepared in two steps from ethyl 2-(2-fluorobenzoyl)acetate. Treatment of this β-ketoester with N,N-dimethylformamide dimethyl acetal gives a

Novel 3-(4-oxo-4h-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same

Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or different, each represent a group selected from hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR′ wherein R′ represents an ionised or ionisable group, R5 represents a group selected from alkyl, aryl and heteroaryl, R7 represents a group selected from hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogen-containing or oxygen-containing heterocycle, its optical isomers, hydrates and solvates thereof and addition salts thereof, with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.

Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties

A novel series of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones has been prepared. These compounds showed good PDE 4 inhibitory activity and weak affinity for rolipram's binding site. They also exhibited a good anti-inflammatory profile without emetic side effects. (C) 2000 Published by Elsevier Science Ltd.