23120-57-2Relevant academic research and scientific papers
The hydrodeoxygenation of bioderived furans into alkanes
Sutton, Andrew D.,Waldie, Fraser D.,Wu, Ruilian,Schlaf, Marcel,'Pete'Silks, Louis A.,Gordon, John C.
, p. 428 - 432 (2013)
The conversion of biomass into fuels and chemical feedstocks is one part of a drive to reduce the world's dependence on crude oil. For transportation fuels in particular, wholesale replacement of a fuel is logistically problematic, not least because of the infrastructure that is already in place. Here, we describe the catalytic defunctionalization of a series of biomass-derived molecules to provide linear alkanes suitable for use as transportation fuels. These biomass-derived molecules contain a variety of functional groups, including olefins, furan rings and carbonyl groups. We describe the removal of these in either a stepwise process or a one-pot process using common reagents and catalysts under mild reaction conditions to provide n-alkanes in good yields and with high selectivities. Our general synthetic approach is applicable to a range of precursors with different carbon content (chain length). This allows the selective generation of linear alkanes with carbon chain lengths between eight and sixteen carbons.
Towards Improved Biorefinery Technologies: 5-Methylfurfural as a Versatile C6 Platform for Biofuels Development
Galkin, Konstantin I.,Ananikov, Valentine P.
, p. 185 - 189 (2018/12/05)
Low chemical stability and high oxygen content limit utilization of the bio-based platform chemical 5-(hydroxymethyl)furfural (HMF) in biofuels development. In this work, Lewis-acid-catalyzed conversion of renewable 6-deoxy sugars leading to formation of more stable 5-methylfurfural (MF) is carried out with high selectivity. Besides its higher stability, MF is a deoxygenated analogue of HMF with increased C/O ratio. A highly selective synthesis of the innovative liquid biofuel 2,5-dimethylfuran starting from MF under mild conditions is described. The superior synthetic utility of MF against HMF in benzoin and aldol condensation reactions leading to long-chain alkane precursors is demonstrated.
Method for synthesizing functionalized 1,3-butadiene based on biomass chemicals
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Page/Page column 0197-0199, (2019/04/26)
The invention provides a method for synthesizing functionalized 1,3-butadiene based on biomass chemicals. The method includes the following steps that under the effect of a condensation catalyst, acetone and a furfural compound are subjected to a condensation reaction, and then a condensation product is obtained; the furfural compound comprises furfural or derivatives of the furfural; then under the effect of a reduction catalyst, the condensation product obtained in the step is subjected to a reduction reaction, and then a reduction product is obtained; under the effect of a catalyst, the reduction product obtained in the step is subjected to a dehydration reaction, and then the functionalized 1,3-butadiene is obtained. According to the method, the acetone and the furfural compound whichare low in cost and easily obtained can be used as raw materials, the functionalized 1,3-butadiene is compounded, experiment conditions are mild, operation is easy, and the method has large-scale synthetic prospects.
Compound capable of effectively inhibiting or killing multi-drug resistant bacteria and preparation method and application of compound
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Paragraph 0159; 0160; 0535, (2017/06/02)
The invention discloses a compound capable of effectively inhibiting or killing bacterial microorganisms. The compound has a structural general formula shown as the formula I (please see the formula in the description). Pharmacodynamic experiments prove that the compound can effectively inhibit or kill the broad-spectrum and multi-drug resistant staphylococcus aureus, streptococcus pneumoniae and staphylococcus aureus and is expected to be developed into a novel effective antibacterial drug with new targets.
Functional group dependence of the acid catalyzed ring opening of biomass derived furan rings: An experimental and theoretical study
Waidmann, Christopher R.,Pierpont, Aaron W.,Batista, Enrique R.,Gordon, John C.,Martin, Richard L.,Pete Silks,West, Ryan M.,Wu, Ruilian
, p. 106 - 115 (2013/03/29)
We describe studies of Bronsted acid catalyzed ring opening of substituted furans contained within biomass derived C8- and C9- molecules. Ring opening occurs homogeneously under relatively mild conditions of 80°C using catalytic hydrochloric acid. In the case of 4-(5-methyl-2-furyl) -2-butanone (1a), the reaction proceeds to a single product in up to 92% yield after 24 hours. For 4-(2-furanyl)-2-butanone (1b) and 4-(5-hydroxymethyl)-2- furanyl-2-butanone (1c), however, multiple products are observed, illustrating the significant influence of furan ring substituents on the reactivity of this class of compounds. The generality of these reaction pathways was tested using several other similar substrates. Kinetics experiments indicate that ring opening of 1a occurs via specific acid catalysis, and computations elucidate the effect of initial protonation on the reaction pathway. Calculated pK a values were calibrated against experimentally measured values and are consistent with observed reactivities. Inclusion of explicit, hydrogen-bonded water molecules in addition to the SMD solvent model is necessary when studying protonation of alcohol and ketone groups. The Royal Society of Chemistry 2013.
FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS
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, (2008/06/13)
Substituted furan and pyrrole compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase.
Substituted furan compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase
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, (2008/06/13)
Substituted furan and pyrrole compounds of formula (I) which are useful in inhibiting lipoxygenase enzymes, particuarly 5-lipoxygenase.
