23125-28-2

Usage

Safety Profile

A poison by intravenous route. When heated to decomposition it emits toxic vapors of NO,x

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 141-97-9 ethyl acetoacetate 
• 626-34-6 ethyl 3-aminobut-2-enoate 

Downstream Products

• 78005-05-7 3',5'-Bis-ethoxycarbonyl-1,2',6'-trimethyl-1',4'-dihydro-[2,4']bipyridinyl-1-ium; iodide 
• 581-47-5 4-(2-pyridyl)pyridine 

Relevant academic research and scientific papers

Experimental and theoretical structural study of 2-pyridyl- and 4-hydroxyphenyl-1,4-dihydropyridine derivatives

A series of substituted 1,4-dihydropyridines (1,4-DHPs) has been synthesised following the well-known Hantzsch's procedure for symmetrical 1,4-DHP. The structures of these compounds have been thoroughly studied by X-ray crystallographic analysis and semie

USY-zeolite catalyzed synthesis of 1,4-dihydropyridines under microwave irradiation: structure and recycling of the catalyst

The Hantzsch three-component reaction is the best-known multicomponent reaction, affording dihydropyridines which have been employed therapeutically and also as visible‐light photoredox catalysts. In this work we report the application of an ultra-stable

Diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivative for inducing cell apoptosis, a method for producing the same, and an anticancer drug containing the same

The present invention relates to a diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivative which induces cell apoptosis, a method of manufacturing the same, and an anti-cancer drug containing the same. A compound represented by chemical form

MIL-101-SO3H metal-organic framework as a Br?nsted acid catalyst in Hantzsch reaction: An efficient and sustainable methodology for one-pot synthesis of 1,4-dihydropyridine

A straightforward and efficient methodology for the one-pot multicomponent synthesis of 1,4-dihydropyridine has been developed using MIL-101-SO3H metal-organic framework as a solid Br?nsted acid. The presence of the uniformly distributed Br?nsted acidic sulfonic acid sites throughout the framework and the high stability bestow the catalyst with excellent reactivity towards the synthesis of 1,4-dihydropyridine under simple reaction conditions using renewable ethanol as the solvent. The present methodology tolerates various functional groups and allows the synthesis of 1,4-dihydropyridine derivatives in good to excellent yields through Hantzsch reaction. The developed methodology proceeds under mild conditions, avoids corrosive reagents and special reaction conditions, and is amenable to gram scale synthesis. The sustainable nature of the catalyst was proved by the easy recovery and the reusability of the catalyst, as it was reused several times without loss in activity, which was confirmed from the FTIR, PXRD and SEM analyses of the reused catalyst.

Compatibility of supported ionic liquid phase catalysts under ultrasonication

Various supported ionic liquid phase (SILP) catalysts containing hexafluorophosphate anion have been prepared by covalent grafting of imidazolium ionic liquid in the matrix of cellulose, silica and Merrifield resin followed by anion metathesis reaction. T

Synthetic diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates induce apoptosis

Background: The Hantzsch ester, diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, has been used as a hydride donor and its various biological effects have been reported. To identify chemotherapeutic agents with apoptotic effects, 21 diethyl 2,6-

Synthesis of diethyl 4-(phenyl-substituted)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates catalyzed by CoCl2/K-10 montmorillonite in water and their antimicrobial activity

A simple and efficient method of one pot synthesis of 1,4-dihydropyridine by three components reaction of aromatic aldehydes with 1,3-dicarbonyl compound, ammonium acetate and catalytic amount of CoCl2 based on the Hantszch reaction is developed. The process is catalysis by an inexpensive catalyst in water medium, gives high yield of products and involves no volatile organic solvents. Some synthesized compounds demonstrated antimicrobial activity.

Fe3O4@SiO2 supported aza-crown ether complex cation ionic liquids: preparation and applications in organic reactions

A series of aza-crown ether ionic liquids supported on magnetic Fe3O4@SiO2 core-shell particles were designed, synthesized and characterized by elemental analysis, TEM, TG and FT-IR. These new aza-crown ether complex cation ionic liquids were utilized as heterogeneous acidic catalysts in Friedel-Crafts alkylation and Hantzsch reaction in good yields under convenient reaction conditions. Moreover, these magnetic particle supported IL catalysts could be readily recovered by an external magnet and reused five times without obvious loss of activity.

Heterogeneous bimetallic ZnFe2O4nanopowder catalyzed synthesis of Hantzsch 1,4-dihydropyridines in water

The mixed metal oxide ZnFe2O4nanopowder, a dual Lewis acid–base combined catalyst is found to efficiently catalyze a multicomponent synthesis of 1,4-dihydropyridines from aldehydes, ethyl acetoacetate, and ammonium acetate in water. This procedure offers several advantages including high yields, short reaction times, a simple work-up procedure, and a benign eco-footprint. This method takes advantage of the fact that water, a green solvent is used in combination with ZnFe2O4nanoparticles as catalyst which can be easily recovered magnetically and reused for further runs.

USE OF COMPOSITIONS OBTAINED BY CALCINING PARTICULAR METAL-ACCUMULATING PLANTS FOR IMPLEMENTING CATALYTICAL REACTIONS

The use of metal-accumulating plants for implementing chemical reactions especially catalytical reactions.