23145-99-5

Basic information

• Product Name: Piperazine, 1-(3-chloropropyl)-4-(phenylmethyl)-
• CAS NO: 23145-99-5
• Molecular Formula: C14H21ClN2
• Molecular Weight: 252.787
• Mol File: 23145-99-5.mol

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(3-chloropropyl)-4-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(3-chloropropyl)-4-(phenylmethyl)-(23145-99-5)
• EPA Substance Registry System: Piperazine, 1-(3-chloropropyl)-4-(phenylmethyl)-(23145-99-5)

Safety Data

• Hazardous Substances Data: 23145-99-5(Hazardous Substances Data)

Upstream product

• 2759-28-6 1-phenylmethylpiperazine 
• 7440-44-0 pyrographite 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 1363773-47-0 3-(4-benzylpiperazino)propyl [5-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl]sulfide 
• 1456543-23-9 1-[3-(4-benzylpiperazino)propyl]-3-(4-fluorophenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione 
• 1250257-10-3 C₂₃H₂₈N₄OS 
• 1250257-12-5 C₂₂H₂₅ClN₄OS 
• 1250257-11-4 C₂₃H₂₈N₄OS 
• 93699-34-4 1-(4-Chlorophenyl)-1-{4-[3-(4-benzyl-piperazin-1-yl)-propoxy]-phenyl}-propan-1-ol 
• 1350839-70-1 2-[3-(4-benzylpiperazin-1-yl)propyl]-4-furan-2-ylmethyl-6-phenyl-2H-pyridazin-3-one 
• 1350839-68-7 4-benzyl-2-[3-(4-benzylpiperazin-1-yl)propyl]-6-phenyl-2H-pyridazin-3-one 
• 1034266-09-5 C₂₁H₂₉N₃O₃S 
• 1034266-45-9 C₂₄H₂₉N₃O₂S 

Relevant articles and documents

Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives

A series of 3-[3-[4-(substituted)-1-cyclicamine] propyl]thio-5- substituted[1,2,4]triazoles (8a-m) and 2-[3-[4-(substituted)-1-cyclicamine] propyl]-5-(substituted)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (9a-h) were synthesized with good yields starting from corresponding carboxylic acids using two different methods. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Six compounds had shown good anticancer activity. The triazole derivatives, 9d, 8j, and 8i were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activity. Springer Science+Business Media 2013.

Synthesis of new S-alkylated-3-mercapto-1,2,4-triazole derivatives bearing cyclic amine moiety as potent anticancer agents

A series of 3-[3-[4-(Substituted)-1-cyclicamine]propyl]thio-5- substituted[1,2,4]triazoles (8a-j) were synthesized with good yields starting from corresponding carboxylic acids. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Three compounds had shown good anticancer activity. The triazole derivatives, 8i and 8j were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinants of their biological activity.

Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substitutedpiperazine-1-yl) propyl]pyridazin-3(2H)-one derivatives as anticancer agents

A series of new 4-(aryl/heteroaryl-2-ylmethyl)- 6-phenyl-2-[3-(4- substituted piperazine-1-yl)propyl] pyridazin- 3(2H)-one derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H NMR, and mass spectral data. All the compounds were evaluated for their cytotoxicity toward five human cancer cell lines of different origins viz; HeLa (Cervical), SKBR3 (Breast), HCT116 (Colon), A375 (Skin) & H1299 (Lung) at different concentrations and the IC50 values were determined. HCT116 and HeLa are the most sensitive against the compounds studied. One of them displayed moderate cytotoxicity against SKBR3. Majority of the compounds exhibited good to moderate activity.

Preparation of piperazine derivatives as 5-HT7 receptor antagonists

Twenty-four compounds of 4-methoxy-N-[3-(4-substituted phenyl-piperazine-1-yl)propyl] benzene sulfonamides and N-[3-(4-substituted phenyl-piperazine-1-yl)propyl] naphthyl sulfonamides were prepared and evaluated as 5-HT7 receptor antagonists. Most of the compounds showed the IC50 values of 12-580 nM. Four methyl branched analogues were also obtained, but the activity for methyl branched analogues was almost same as its straight chain congeners. Among the synthesized compounds, 3c showed a good activity on 5-HT7 receptors and a good selectivity on 5-HT1a, 5-HT2a, 5-HT2c, and 5-HT6 receptors.

Microwave-assisted solvent-free synthesis of 3-[(4-substituted piperazin-1-yl)alkyl] imidazo[2,1-b][1,3]benzothiazol-2(3H)-ones as serotonin3 (5-HT3) receptor antagonists

A series of novel 3-[(4-substituted piperazin-1-yl)alkyl]imidazo[2,1-b][1, 3]benzothiazol-2(3H)-ones were prepared by microwave irradiation using alumina as solid support and also by a conventional method. The compounds were characterized by spectral data and the purity was ascertained by microanalysis. The synthesized compounds were evaluated for 5-hydroxytryptamine3 antagonisms in a longitudinal muscle-myenteric plexus preparation from guinea pig ileum against the 5-hydroxytryptamine3 agonist, 2-methyl-5-hydroxytryptamine. Among the test compounds, 3-[2-(4-methylpiperazin- 1-yl)ethyl]imidazo[2,1-6][1,3]benzothiazol-2(3H)-one (3b) showed most favorable 5-hydroxytryptamine3 antagonism (pA2 6.7) in the isolated guinea pig ileum.

Zinc mediated alkylation of cyclic secondary amines

Zinc metal mediated simple and efficient alkylation of cyclic secondary amines e.g., piperazines and morpholine with allyl bromide, chlorobromo propane and p-methoxy benzyl bromide is described in good yields.

Protected aminofunctionalized polymerization initiators and methods of making and using same

Anionic polymerization initiators useful in the preparation of polymers having a protected amine functional group. The amine functionality is part of a heterocyclic radical and includes a protecting group.

Pyridine and pyridazine derivatives, processes for the production thereof and pharmaceutical agents containing these compounds

Compounds of Formula I STR1 in which the variables are defined herein, processes for the production thereof as well as pharmaceutical agents containing these compounds for the treatment of diseases which are the result of thromboembolytic events.

Synthesis and trazodone-like pharmacological profile of 1- and 2--propyl>benzotriazoles

A series of 1- and 2--propyl>benzotriazoles were prepared and evaluated for their trazodone-like pharmacological profile; as preliminary pharmacological screening, the compounds were tested for their antiserotonergic, antiadrenergic and antihistaminic in vitro activity as well as for their analgesic in vivo action.Structure-activity relationships showed that among the synthesized compounds, the analogues bearing on the 4-piperazine nitrogen either an unsubstituted phenyl ring or a 2- or 3-chloro phenyl moiety show a pharmacological profilesimilar to that of the antidepressant trazodone. benzotriazoles / antiserotonergic / antiadrenergic / antihistaminic/ analgesic