23153-74-4

Usage

InChI:InChI=1/C8H14O3/c9-6-7-2-1-3-8(7)10-4-5-11-8/h7,9H,1-6H2

Upstream product

• 23153-73-3 ethyl 1,4-dioxaspiro[4,4]nonane-6-carboxylate 
• 20618-42-2 2-(hydroxymethyl)cyclopentanone 
• 107-21-1 ethylene glycol 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 10472-24-9 methyl 2-oxocyclopentane-1-carboxylate 
• 7757-82-6 sodium sulfate 
• 120-92-3 cyclopentanone 
• 110295-58-4 1,4-dioxa-spiro[4.4]nonane-6-carboxylic acid methyl ester 

Downstream Products

• 20618-42-2 2-(hydroxymethyl)cyclopentanone 
• 130733-87-8 6-(tert-butyldiphenylsilyloxymethyl)-1,4-dioxaspiro<4,4>nonane 
• 66522-88-1 6-Formyl-1,4-dioxaspiro<4.4>nonane 
• 201423-71-4 α-allyloxymethyl-cyclopentanone 
• 88733-69-1 6-benzyloxymethyl-1,4-dioxaspiro[4,4]nonane 
• 68755-19-1 trans-2-hydroxycyclopentanemethanol cyclic phosphoric acid phenyl ester 
• 130733-88-9 2-(((tert-butyldiphenylsilyl)oxy)methyl)cyclopentan-1-one 
• 132591-67-4 5-(4-Chloro-phenylselanylmethyl)-spiro[3.4]octan-1-one 
• 132591-63-0 6-(4-Chloro-phenylselanylmethyl)-1,4-dioxa-spiro[4.4]nonane 
• 132591-65-2 2-(4-Chloro-phenylselanylmethyl)-cyclopentanone 
• 132591-69-6 5-(4-Chloro-phenylselanylmethyl)-spiro[3.4]octane 
• 76909-91-6 rel-(1R,5R)-5-(hydroxymethyl)cyclopent-2-en-1-ol 
• 62138-01-6 (+/-)-(1α,2α,3β,5β)-3-amino-5-(hydroxymethyl)-1,2-cyclopentanediol 

Relevant academic research and scientific papers

Synthetic studies directed toward the total synthesis of a jatrophane diterpene

Jatrophane diterpenes are of significant biological importance as they have shown a remarkable potential as a Pgp inhibitor. These diterpenes have a characteristic framework. Synthesis of an advanced synthon was achieved in high yielding steps. The methyl

Z-Selective Horner-Wadsworth-Emmons reaction of 2-TOM-cyclopentanone for the synthesis of rac-N-Cbz-Gly-Ψ[(Z)-CFC]-Pro-OH dipeptide isostere

The Horner-Wadsworth-Emmons reactions of 2-fluoro-2-diethylphosphonoacetic acid with 2-{[(triisopropylsilyl)oxy]methyl}cyclopentanone (2-TOM-cyclopentanone) using methylmagnesium chloride furnished the corresponding tetra-substituted fluoroolefin in a Z-selective manner (E/Z = 9:91). A facile synthesis of rac-N-Cbz-Gly-Ψ[(Z)-CFC]-Pro-OH as a dipeptide isostere was achieved based on the Z-selective Horner-Wadsworth-Emmons reaction.

SPIROHYDANTOIN COMPOUNDS AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS

The present invention relates to a compound of formula (1-1 ) in free form or in pharmaceutically acceptable salt form in which the substituents are as defined in the specification; to its preparation, to its use as a medicament and to medicaments comprising it. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Efforts toward the total synthesis of a jatrophane diterpene

A significant effort toward the model study of jatrophane skeleton has been made. To synthesize an important synthon, Horner-Emmons-Wadsworth olefination was attempted.

Benzimidazole compound

An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

Synthesis and photoinitiated radical cyclization of allyl- and propynyloxymethyl substituted cyclopentanones to tetrahydrocyclopenta[c]furanols

Bicyclic cyclopentafuranols were formed by photoinitiated radical cyclization of allyl- and propinyloxymethyl substituted cyclopentanones with high regioselectivity. The irradiations were carried out at a wavelength of 300 nm in aprotic solvents such as benzene and acetonitrile. We could also show that reductive photoinduced electron transfer (PET) of the propynyloxymethyl substituted cyclopentanone 5 does not lead to any cyclization. The starting materials were synthesized in good yields following known procedures.

Microbiological transformations 60. Enantioconvergent baeyer-villiger oxidation via a combined whole cells and ionic exchange resin-catalysed dynamic kinetic resolution process

A dynamic kinetic resolution process was applied to an enantioconvergent microbial Baeyer-Villiger oxidation of benzyloxycyclopentanone, rac-1. This was achieved by combining a whole cell-based kinetic resolution and an anion exchange resin-catalysed in s

Cathodic cyclisation of N-(oxoalkyl)pyridinium salts - Formation of tricyclic indolizidine and quinolizidine derivatives in aqueous medium

The cathodic cyclisation of N-(oxoalkyl)pyridinium salts, derived from 4-methylpyridine and cyclic ketones, afforded functionalised tricyclic indolizidine and quinolizidine derivatives in high yields. Through systematic variation of the ring size of the k

Baeyer-Villiger oxidations catalyzed by engineered microorganisms: Enantioselective synthesis of δ-valerolactones with functionalized chains

Cyclohexanone monooxygenase (CHMO) from Acinetobacter sp NCIMB 9871 expressed in baker's yeast and in E. coli and cyclopentanone monooxygenase (CPMO) from Comamonas (previously Pseudomonas) sp. NCIMB 9872 expressed in E. coli are new bioreagents for Baeye

Sequential Ketyl-Olefin Coupling/β-Elimination Reactions Mediated by Samarium(II) Iodide

Samarium(II) iodide (SmI2) has been employed in an intramolecular sequential ketyl-olefin coupling/β-elimination reaction. The overall process results in the net addition of an alkenyl species to a ketone carbonyl. This novel protocol for the intramolecular delivery of an alkenyl moiety avoids the basic reaction conditions typical of nucleophilic additions that are mediated by alkenylmagnesium halides and alkenyllithium reagents. A high degree of stereocontrol is imparted in the SmI2-mediated process as a result of the excellent facial selectivity conveyed in the initial ketyl-olefin coupling reaction. The relative asymmetric induction engendered in these addition reactions is complementary to more traditional nucleophilic addition reactions in that the alkenyl group is directed to the carbonyl center by an attached tether.