23155-55-7Relevant academic research and scientific papers
Synthesis of pyrimidines, thienopyrimidines and pyrazolopyrimidine
Kamal El-Dean, Adel M.,Abdel-Moneam, Maisa E.
, p. 1057 - 1060 (2002)
5-Ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6(1H)-thione (3), which was prepared from the reaction of ethyl β-aminocrotonate 1 with benzoyl isothiocyanate (2) in refluxing acetone, was reacted with halo compounds to give S-alkyl derivatives 4a-h. Treatment of compounds 4a-c with sod. ethoxide cyclized into thienopyrimidine 10a-c. Hydrazinolysis of compound 3 gave hydroxypyrazolopyrimidine derivative 6. Also the latter compound was obtained upon heating compound 4a with hydrazine hydrate under neat conditions, but when compound 4a refluxed with hydrazine hydrate in ethanol the corresponding carbohydrazide 5 was produced.
Synthesis and structural studies of 4-thioxopyrimidines with antimicrobial activities
Cunha, Silvio,Bastos, Rodrigo M.,Silva, Priscila De O.,Costa, Giselle A. Nobre,Vencato, Ivo,Lariucci, Carlito,Napolitano, Hamilton B.,De Oliveira, Cecilia M. A.,Kato, Lucilia,Da Silva, Cleuza C.,Menezes, Diego,Vannier-Santos, Marcos A.
, p. 111 - 119 (2007/10/03)
This work describes a two-step, one-pot synthetic method for the formal aza-[3 + 3] cycloaddition between N-alkyl substituted enaminones and benzoyl isothiocyanate, which afforded 4-thioxopyrimidines in reasonable yields. Reaction of acyclic enaminone wit
Synthesis of pyrimidines, thienopyrimidines, and pyrazolopyrimidines
Kamal El-Dean, Adel M.,Abdel-Moneam, Maisa E.
, p. 2745 - 2751 (2007/10/03)
5-Ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6(1H)-thione (3), which was prepared from the reaction of ethyl β-aminocrotonate 1 with benzoyl isothiocyanate (2) in refluxing acetone, was reacted with a series of halopgenated reagents to give S-alkyl derivatives 4a-g. Upon treatment of compounds 4a-c with sodium ethoxide were cyclized into thienopyrimidine 10a-c. Pyrimidinethione 3 was reacted with hydrazine hydrate to give hydroxypyrazolopyrimidine derivative 6. The later compound was obtained by heating compound 4a with hydrazine hydrate under neat conditions, but when the reaction was carried using hydrazine hydrate in ethanol, the corresponding carbohydrazide 5 was produced.
REACTIONS OF CARBONYL ISOTHIOCYANATES WITH ENAMINES OF THE TYPE CH3-C(NH2)=CH-X
Uher, Michal,Ilavsky, Dusan,Foltin, Jozef,Skvareninova, Katarina
, p. 3128 - 3133 (2007/10/02)
Reactions of carbonyl isothiocyanates with enamines of the type CH3-C(NH2)=CH-X (X = CN, COOC2H5, or COCH3) were investigated.The formation of products of AdN, SN, and cyclization reactions is discussed on the basis of their IR, UV a
