871984-22-4

Upstream product

• 871984-19-9 ethyl 4-(4-fluorophenylamino)-6-methyl-2-phenylpyrimidine-5-carboxylate 
• 871984-20-2 4-(4-fluorophenylamino)-6-methyl-2-phenylpyrimidine-5-carboxylic acid 
• 23155-55-7 ethyl 4-methyl-2-phenyl-6-thioxo-1,6-dihydro-5-pyrimidinecarboxylate 
• 371-40-4 4-fluoroaniline 
• 871984-21-3 4-(4-fluorophenylamino)-5-hydroxymethyl-6-methyl-2-phenylpyrimidine 

Downstream Products

• 871984-23-5 5-aminomethyl-4-(4-fluorophenylamino)-6-methyl-2-phenylpyrimidine 
• 871984-29-1 3-[(4-acetaminophenyl)sulfonyl]-1-(4-fluorophenyl)-5-methyl-7-phenyl-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine 
• 871984-24-6 1-(4-fluorophenylamino)-5-methyl-7-phenyl-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine 

Relevant academic research and scientific papers

A new pyrimidine schiff base with selective activities against enterococcus faecalis and gastric adenocarcinoma

Enterococcus faecalis is known as a significant nosocomial pathogen due to its natural resistance to many antibacterial drugs. Moreover, it was found that E. faecalis infection causes inflammation, production of reactive oxygen species, and DNA damage to human gastric cancer cells, which can induce cancer. In this study, we synthesized and tested the biological activity of a new Schiff base, 5-[(4-ethoxyphenyl)imino]methyl-N-(4-fluorophenyl)-6-methyl-2-phenylpyrimidin-4-amine (3), and compared its properties with an analogous amine (2). In the biological investigation, 3 was found to have antibacterial activity against E. faecalis 29212 and far better anticancer properties, especially against gastric adenocarcinoma (human Caucasian gastric adenocarcinoma), than 2. In addition, both derivatives were non-toxic to normal cells. It is worth mentioning that 3 could potentially inhibit cancer cell growth by inducing cell apoptosis. The results suggest that the presence of the –C=N– bond in the molecule of 3 increases its activity, indicating that 5-iminomethylpyrimidine could be a potent core for further drug discovery research.

Synthesis and antibacterial properties of pyrimidine derivatives

The paper presents the synthesis of 1,2,3,7-tetraaryl-1,2,3,4- tetrahydropyrimido[4,5-d]pyrimidines. The structures of the obtained compounds were confirmed by crystallographic and spectroscopic analyses, and their antibacterial activity was tested on 9 s

Synthesis and antimicrobial properties of 3-sulfonyl-1,2,3,4-tetrahydropyrimido [4,5-d] pyrimidines.

The paper presents the synthesis of sulfonyl tetrahydropyrimido[4,5-d]pyrimidine derivatives as well as the antimicrobial activity of the obtained compounds. The investigations showed that the obtained sulfonyl derivatives of pyrimido[4,5-d]pyrimidines and especially the compounds with free amino group reveal interesting antibacterial and antifungal activity.