2316-62-3Relevant academic research and scientific papers
Synthesis of biaryl compounds through three-component assembly: Ambidentate effect of the tert-butyldimethylsilyl group for regioselective diels-alder and hiyama coupling reactions
Akai, Shuji,Ikawa, Takashi,Takayanagi, Sho-Ichi,Morikawa, Yuki,Mohri, Shinya,Tsubakiyama, Masaya,Egi, Masahiro,Wada, Yasufumi,Kita, Yasuyuki
supporting information; experimental part, p. 7673 - 7676 (2009/04/10)
Two for the price of one: A method has been developed for the regiocontrolled synthesis of multisubstituted biaryl derivatives. This protocol involves the use of the tert-butyldimethylsilyl (TBDMS) group to direct the regioselective Diels-Alder reaction of a 3-TBDMS-benzyne with a furan derivative and a subsequent Hiyama cross-coupling reaction of the TBDMS group with aryl iodides (see scheme).
Synthesis of some hydroxymethylbromophenols of marine origin
Sudalai, A.,Rao, G. S. Krishna
, p. 858 - 859 (2007/10/02)
The hydroxymethylbromophenols 5, 7 and 9, isolated from marine source have been prepared in good yield.The bromo derivatives 1 and 2 of vanillin are demethylated to 4 and 6 which on borohydride reduction furnish 5 and 7 respectively.The dibromo-p-cresol (3) is oxidised to the aldehyde 8 which on borohydride reduction affords 9.
