231629-76-8Relevant academic research and scientific papers
Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues
Ostrowski, Tomasz,Golankiewicz, Bozenna,De Clercq, Erik,Balzarini, Jan
, p. 2089 - 2096 (2005)
A series of fluorine containing tricyclic analogues of acyclovir (ACV, 1) and ganciclovir (GCV, 2) were synthesized and evaluated for their activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) and cytostatic activity against HSV-1 thymi
Substituent-directed aralkylation and alkylation reactions of the tricyclic analogues of acyclovir and guanosine
Ostrowski,Zeidler,Goslinski,Golankiewicz
, p. 1911 - 1929 (2007/10/03)
Aryl or tert-butyl substituent in the 6 position of 3,9-dihydro-3-[(2-hydroxyethoxy)methyl]-9-oxo-6-R-5H-imidazo[1,2-a]purine (6-R-TACV)11 partly directs aralkylation reactions into unusual positions: N-4 to give 3 and C-7 to give N-5,7-disubst
A convenient approach to N-3 alkylation of 9-substituted guanines
Ostrowski, Tomasz,Zeidler, Joanna,Goelizski, Tomasz,Golankiewicz, Bozenna
, p. 565 - 567 (2007/10/03)
Aryl or tert-butyl substituent in the 6 position of 3,9-dihydro-3-[(2- hydroxy-ethoxy)methyl]-9-oxo-6-R-5H-imidazo[1,2-a]purine 1 directs the benzylation reaction partly into N-4 position to give 3. Cleavage of the third ring of 3 gives 3-benzylacycloguan
