231633-55-9Relevant academic research and scientific papers
A palladium-catalyzed asymmetric allylic alkylation approach to α-quaternary γ-butyrolactones
De Oliveira, Marllon Nascimento,Fournier, Jeremy,Arseniyadis, Stellios,Cossy, Janine
, p. 14 - 17 (2017/11/27)
The Pd-catalyzed asymmetric allylic alkylation (Pd-AAA) of enol carbonates derived from γ-butyrolactones is reported, affording the corresponding enantioenriched α,α′-disubstituted γ-butyrolactones in both high yields and high enantioselectivities (up to 94% ee). This method was eventually applied to the synthesis of chiral spirocyclic compounds.
Dual nucleophilic/electrophilic capture of in situ generated iminium ethers: Towards the synthesis of functionalized amide building blocks
Peng, Bo,O'Donovan, Daniel H.,Jurberg, Igor D.,Maulide, Nuno
, p. 16292 - 16296 (2013/02/22)
Rearranging its feathers: The transformation of simple linear amides into a diverse range of branched, functionalized products by conversion to iminium esters is followed by sequential treatment with nucleophiles and electrophiles (see scheme). The method takes advantage of a novel Claisen rearrangement and the use of aromatic substrates greatly facilitates the formation of the intermediate iminium ether.
Diastereoselective double ring closing metathesis reactions as an approach to symmetrical bicyclodienes
Lautens,Hughes,Zunic
, p. 868 - 883 (2007/10/03)
A new class of bicyclic dienes which contain a σ plane of symmetry are efficiently prepared in a diastereoselective fashion using ring closing metathesis reactions. These molecules have potential as starting materials for a wide range of organic targets.
