231935-89-0Relevant academic research and scientific papers
Studies with polyfunctionally substituted heteroarenes: New synthesis of benzo [c] quinolinones and pyrano [3,2-c] quinoline derivatives
El-Taweel,Sowellim,Elagamey
, p. 325 - 333 (2007/10/03)
Nitration, bromination and acetylation of 4 - hydroxypyranoquinolines 1 yielded 3-nitro-, 3-bromo, and 3-acetylpyranoquinolines 3,5,8. Hyrolysis of 3, 5 and 8 with 2N NaOH afforded 3-nitroacetyl, 3-bromoacetyl and 3- acetylquinolines 4, 6 and 7 respectively. Formylation of 1 or 7 gave 3- formyl pyranoquinolines 9a-c. Reactions of 8 with 2 afforded benzo [c] quinolines 11 and 12. Treatment of 1, 24 or 7 with the ylidene 21 resulted in the formation of pyranoquinolines 25.
