23195-62-2Relevant articles and documents
Synthesis, crystal structure and magnetic properties of new copper(II) complexes based on 3-(2-pyridyl)-1,2,4-triazole
Petrenko, Yuliia P.,Khomenko, Dmytro M.,Doroshchuk, Roman O.,Shova, Sergiu,Novitchi, Ghénadie,Piasta, Karolina,Gumienna-Kontecka, Elzbieta,Lampeka, Rostyslav D.
, (2020)
The synthesis, crystal structure, spectroscopic and magnetic properties of binuclear [Cu2(L)2(SO4)(H2O)3]·3H2O (4a) and tetranuclear [Cu4(HL)2(L)4(DMF)2(SO4)2]·DMF (4b) copper(II) complexes were reported (where HL is 3-(pyridine-2-yl)-1,2,4-triazole). Potentiometric titrations, ESI-MS and spectrophotometric studies of complex formation in MeOH/H2O solutions indicated the presence of monomeric [CuHL]2+, dinuclear [Cu2L2]2+ and [Cu2L2(OH)]+, and trinuclear [Cu2L3]+ and [Cu2L3(OH)] species. The small N,N-nucleating ligand HL leads to a supramolecular formation of the complexes. The ligand comprises a triazole moiety substituted by pyridine group, strategically located to form chelate metalocycles. The basis of both complexes is two metal centres bridged via N1–N2 diazine grouping of a triazole ring. For complex 4b two HL coordinate in acidoform via NPy and N4 of azole moiety as well. There are significant differences in the polyhedrons, namely nuclearity and Cu…Cu separations. Complexes were characterized by elemental analysis, mass-spectrometry, IR- spectroscopy and X-ray analysis. Magnetic measurements revealed that both compounds exhibit antiferromagnetic interaction. The magnetic susceptibility data were interpreted on the basis of the spin Hamiltonian in the temperature range (2–300 K) using the dinuclear (4a: J1 = ?52.41 cm?1) and tetranuclear (4b: J1 = ?53.10 cm?1 to J2 = ?0.14 cm?1) models.
Structural and Electronic Properties of Iron(II) Complexes of 2-(1,2,4-Triazol-3-yl)pyridine and Substituted Derivatives
Sugiyarto, Kristian H.,Craig, Donald C.,Rae, A. David,Goodwin, Harold A.
, p. 35 - 54 (1995)
Iron(II) and nickel(II) tris(ligand) complexes of 2-(triazol-3-yl)pyridine and the substituted derivatives 2-(1(N)-methyltriazol-3-yl)pyridine and 2-(1,5-dimethyltriazol-3-yl)pyridine have been prepared.Coordination of the dimethyl-substituted ligand via N(4) of the triazolyl moieties is confirmed by structure determination of 2, which has the mer configuration.Tris(2-(1,5-dimethyltriazol-3-yl)pyridine)iron(II) bis(tetrafluoroborate): orthorhombic, space group Pbca, a 11.568(3), b 19.442(4), c 30.551(8) Angstroem, Z 8.The methyl substituents appear to have only a minor influence on the donor properties of the ligands, all three of which have field strengths in the iron(II) quintet singlet crossover region.Temperature-induced singlet quintet transitions occur in salts of the (2+) derivatives in both the solid and solution states.Moessbauer effect studies reveal the complexity of the solid state properties of salts of the iron complex of 2-(1(N)-methyltriazol-3-yl)pyridine and suggest that there is a fundamental change with time in the geometry of the complex cation.The metastable form of the complex hexafluorophosphate salt shows virtually no quadrupole splitting in the spectrum for the quintet state species, which implies high symmetry for the metal ion environment.Moessbauer studies further reveal the presence of multiple iron(II) sites in the lattice for salts containing either the N-methyl or the unsubstituted ligand.
Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity
Roppe, Jeffrey,Smith, Nicholas D.,Huang, Dehua,Tehrani, Lida,Wang, Bowei,Anderson, Jeffrey,Brodkin, Jesse,Chung, Janice,Jiang, Xiaohui,King, Christopher,Munoz, Benito,Varney, Mark A.,Prasit, Petpiboon,Cosford, Nicholas D. P.
, p. 4645 - 4648 (2007/10/03)
The highly potent, selective, and brain-penetrant metabotropic glutamate subtype 5 (mGlu5) receptor antagonists 3-(5-pyridin-2-yl-2H-tetrazol-2-yl) benzonitrile (47) and 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile (48) are reported. Compound 47 is active in the rat fear-potentiated startle (FPS) model of anxiety with ED50 = 5.4 mg/kg (po) when dosed acutely. In this model the anxiolytic effects of 47 rapidly tolerate on repeated dosing.