2322-04-5Relevant academic research and scientific papers
Application of Grignard reagents to the synthesis of tertiary methylamines via resin-bound oxyiminium ions
Blaney,Grigg,Rankovic,Thoroughgood
, p. 6639 - 6642 (2007/10/03)
The solid-phase synthesis of tertiary methylamines via the nucleophilic displacement of benzotriazole Mannich adducts with Grignard reagents using a hydroxylamine linker is described. The chemistry is exemplified by the synthesis of the MAO inhibitor α-methylpargyline. Also described is the synthesis of the analgesic Tramadol by an alternative one-pot solid-phase Mannich reaction. (C) 2000 Elsevier Science Ltd.
A simple procedure for af-propenylation and af-propynylation of secondary amines
Crock, Piero Dalla,Ferraccioli, Raffaella,Rosa, Concetta L.A.
, p. 107 - 109 (2007/10/03)
A number of tertiary N-allyl- and N-propargyl-substituted amines have been prepared by alkylation of secondary amines under solid-liquid phase-transfer catalysis conditions.
