2322-58-9

Upstream product

• 13222-26-9 2-chloroisobutyryl chloride 
• 62-53-3 aniline 
• 2322-45-4 2-bromo-2-methyl-N-phenylpropanamide 
• 50993-22-1 α-chloro-N-phenyl-isobutyrimidoyl chloride 
• 2760-38-5 2-hydroxy-2-methylpropionanilide 

Downstream Products

• 60687-73-2 N-(2-tert-Butylamino-2-methylpropyl)anilin 
• 82300-07-0 2-tert-Butylamino-2-methyl-N-phenyl-propionamide 

Relevant academic research and scientific papers

Dichloromethane as a chlorination reagent for α-bromocarbonyl compounds in the presence of a copper catalyst

We found that dichloromethane is a powerful chlorinating reagent for the congested 3° and 2° Csp3Br bond of α-bromocarbonyl amides, esters, and ketones. In the presence of an appropriate copper complex as a catalyst, the desired chlorination occurred within an hour. Control experiments revealed that in situ-generated CuCl2 is a key chlorinating agent that reacts with the 3° or 2° alkyl radicals generated by the reaction between an α-bromocarbonyl compound and a Cu(I) salt.