82300-07-0Relevant academic research and scientific papers
HINDERED AMINES. GENERAL SYNTHESIS OF α-(TERT-BUTYLAMINO)-ISOBUTYRAMIDES
Lai, John T.
, p. 595 - 598 (1982)
α-(tert-Butylamino)-isobutyramides (1) can be prepared from α-haloisobutyramides (2) and tert-butylamine with sodium hydroxyde in Favorskii-like reactions.
Copper-Catalyzed Amination of Congested and Functionalized α-Bromocarboxamides with either Amines or Ammonia at Room Temperature
Ishida, Syo,Takeuchi, Kentaro,Taniyama, Nobuhiro,Sunada, Yusuke,Nishikata, Takashi
supporting information, p. 11610 - 11614 (2017/09/11)
There are several reports on the synthesis of alkylamines, but most of the reported methods are not suitable for the synthesis of hindered amines. In this research, we found that a copper catalyst is effective for the formation of congested C?N bonds at room temperature. Control experiments revealed that a copper amide is a key intermediate. Moreover, when a chiral amine was used, a quaternary carbon stereogenic center was created with good selectivity.
