23263-96-9

Basic information

• Product Name: METHYL 4-(5-METHYL-1H-PYRAZOL-3-YL)PHENYL ETHER
• Synonyms: 3-(4-METHOXYPHENYL)-5-METHYL-1H-PYRAZOLE;METHYL 4-(5-METHYL-1H-PYRAZOL-3-YL)PHENYL ETHER;SALOR-INT L233005-1EA
• CAS NO: 23263-96-9
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.23
• Mol File: 23263-96-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 85-87
• Boiling Point: 369.6 °C at 760 mmHg
• Flash Point: 134.7 °C
• Appearance: /
• Density: 1.13 g/cm³
• Vapor Pressure: 2.49E-05mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: METHYL 4-(5-METHYL-1H-PYRAZOL-3-YL)PHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-(5-METHYL-1H-PYRAZOL-3-YL)PHENYL ETHER(23263-96-9)
• EPA Substance Registry System: METHYL 4-(5-METHYL-1H-PYRAZOL-3-YL)PHENYL ETHER(23263-96-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 23263-96-9(Hazardous Substances Data)

Usage

General Description

Methyl 4-(5-methyl-1H-pyrazol-3-yl)phenyl ether is a chemical compound with a slightly complex structure that consists of a methyl group, a pyrazole ring, and a phenyl ring linked together. It belongs to the class of organic compounds known as phenylpyrazoles, which are aromatic compounds containing a benzene ring linked to a pyrazole ring. This specific compound is derived from a pyrazole which has a methyl substituent at one position. The -yl suffix on pyrazol indicates its function as a substituent on the benzene ring, while the ether refers to the oxygen bridge connecting the components together. The scientific applications or effects of this particular compound are not widely documented and could potentially vary based on the context of its use.

InChI:InChI=1/C11H12N2O/c1-8-7-11(13-12-8)9-3-5-10(14-2)6-4-9/h3-7H,1-2H3,(H,12,13)

Upstream product

• 93214-75-6 5-(4-Methoxy-phenyl)-3-methyl-3,4-dihydro-2H-pyrazol-3-ol 
• 196952-70-2 1-(4-methoxyphenyl)buta-2,3-dien-1-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 943-88-4 4-(p-methoxyphenyl)-3-butene-2-one 
• 178261-65-9 3-(dimethylamino)-1-(4-methoxyphenyl)but-2-en-1-one 
• 4023-80-7 1-(4-methoxyphenyl)butan-1,3-dione 
• 93214-71-2 3-(4-Methoxy-phenyl)-5-methyl-3,4-dihydro-2H-pyrazol-3-ol 
• 21399-34-8 1,2-bis(1-(4-methoxyphenyl)ethylidene)hydrazine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 41780-90-9 1-(p-Methoxyphenyl)-buten-3-on-tosylhydrazon 
• 102252-89-1 (Z)-3-amino-1-(4-methoxyphenyl)but-2-en-1-one 

Downstream Products

• 1430100-73-4 1-(3'-phenylquinoxalin-2'-yl)-3-(4-methoxyphenyl)-5-methylpyrazole 
• 1000189-56-9 1-(3'-methylquinoxalin-2'-yl)-3-(4-methoxyphenyl)-5-methylpyrazole 
• 145353-52-2 3-(4-hydroxyphenyl)-5-methyl-1H-pyrazole 
• 316804-99-6 tris[3-(4-methoxyphenyl)-5-methylpyrazol-1-ylmethyl]amine 
• 316805-01-3 1-hydroxymethyl-3-(4-methoxyphenyl)-5-methylpyrazole 

Relevant articles and documents

REACTIONS OF SODIUM SALTS OF TOSYLHYDRAZONE COMPOUNDS WITH SILVER CHROMATE. FORMATION OF INDAZOLE, PYRAZOLE, AND BENZONITRILE DERIVATIVES.

Tropone tosylhydrazone sodium salt was allowed to react with silver chromate to give 2-tosyl-2H-indazole. The reaction is thought to proceed through the cyclization of the hydrazyl radical intermediate. Under the same conditions, sodium salts of m-nitrobenzaldehyde tosylhydrazone (5), benzylideneacetone tosylhydrazone derivatives (7a and 7b), and beta -ionone tosylhydrazone (9) reacted to yield m-nitrobenzonitrile from 5 and pyrazole derivatives from 7a, b, and 9, respectively. m-Nitrobenzonitrile is formed by homolytic fission of nitrogen-nitrogen bond of 5. Formation of the pyrazole derivatives can be explained by intramolecular 1,3-dipolar additions of the corresponding diazo intermediates.

Predicting the catalytic activity of azolium-based halogen bond donors: an experimentally-verified theoretical study

This report demonstrates the successful application of electrostatic surface potential distribution analysis for evaluating the relative catalytic activity of a series of azolium-based halogen bond donors. A strong correlation (R2> 0.97) was observed between the positive electrostatic potential of the σ-hole on the halogen atom and the Gibbs free energy of activation of the model reactions (i.e., halogen abstraction and carbonyl activation). The predictive ability of the applied approach was confirmed experimentally. It was also determined that the catalytic activity of azolium-based halogen bond donors was generally governed by the structure of the azolium cycle, whereas the substituents on the heterocycle had a limited impact on the activity. Ultimately, this study highlighted four of the most promising azolium halogen bond donors, which are expected to exhibit high catalytic activity.

Monohydrochloride Assisted Synthesis of Functionalized Isoxazoles and Pyrazoles from Allenic Ketones: First Synthesis of (Z)-2-Methyl-7H-benzo[b]pyrazolo[5,1-d][1,5]oxazocines

A facile hydrochloride promoted regioselective synthesis of isoxazoles and pyrazoles from 1,2-allenic ketones is reported. The reaction has been scaled up to gram scale. A direct 8-endo dig ring annulations towards the first synthesis of (Z)-2-methyl-7H-b