23294-41-9

Basic information

• Product Name: (+)-Bis[(R)-1-phenylethyl]amine
• Synonyms: (+)-Bis[(R)-1-phenylethyl]aMine, ChiPros|r, 99%, ee 98+%;(R)-bis((R)-1-phenylethyl)aMine;(+)-Bis[(R)-1-phenylethyl]amine 99%;(+)-BIS (R)-1-PHENYLETHYL!AMINE HYDRO-;(+)-Bis[(R)-1-phenylethyl]amine, 99% (99+% EE/GLC);(R,R)-Bis-(1-phenylethyl)amin;(+)-bis[(r)-α-methylbenzyl]amine;(+)-Bis[(R)-1-phenylethyl]amine, ChiPros 99%, ee 98+%
• CAS NO: 23294-41-9
• Molecular Formula: C₁₆H₁₉N
• Molecular Weight: 225.33
• Mol File: 23294-41-9.mol
• Article Data: 57

Chemical Properties

• Melting Point: ~260 °C
• Boiling Point: 86 °C0.05 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 0.985 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00143mmHg at 25°C
• Refractive Index: n20/D 1.5523(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.79±0.29(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 3590931
• CAS DataBase Reference: (+)-Bis[(R)-1-phenylethyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-Bis[(R)-1-phenylethyl]amine(23294-41-9)
• EPA Substance Registry System: (+)-Bis[(R)-1-phenylethyl]amine(23294-41-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• F: 3
• Hazardous Substances Data: 23294-41-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 23294-41-9 differently. You can refer to the following data:
1. (+)-Bis[(R)-1-phenylethyl]amine play a very extensive role of making chirally optically active drugs and compounds. Also as intermediates.
2. (+)-Bis[(R)-1-phenylethyl]amine can be used:In the synthesis of?β-amino acids.In the preparation of chiral C(19)-C(26) and C(27)-C(32) moieties of scytophycin C.To induce enantioselectivity in the deprotonation of prochiral ketones.As a starting material for the synthesis of chiral phenolate ligands through Mannich condensation reaction.In the synthesis of chiral phosphoramidite ligands.To prepare chiral cyclic isoimidium salts, which are further used to synthesize chiral lactones through Diels-Alder reaction.

InChI:InChI=1/C16H19N/c1-13(15-9-5-3-6-10-15)17-14(2)16-11-7-4-8-12-16/h3-14,17H,1-2H3/t13-,14-/m1/s1

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 98-86-2 acetophenone 
• 69350-13-6 N-benzylidene-(S)-α-methylbenzylamine 
• 98-85-1 1-Phenylethanol 
• 40648-92-8 hydrochloride salt of (1S,1'S)-bis(1-phenylethyl)amine 
• 104873-95-2 [(R)-1-(4-Chloro-phenyl)-ethyl]-((R)-1-phenyl-ethyl)-amine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 618-36-0 rac-methylbenzylamine 
• 40636-57-5 (αS)-α-methyl-N-(1-phenylethylidene)benzenemethanamine 
• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 10024-74-5 (R,R)-N,N-bis-(1-phenylethyl)amine 
• 21003-56-5 (1S,1'S)-bis(1-phenylethyl)amine 
• 20989-17-7 Phenylglycinol 
• 2835-06-5 phenylglycin 

Downstream Products

• 232267-74-2 (S)-3-[Bis-((S)-1-phenyl-ethyl)-amino]-hept-6-enoic acid ethyl ester 
• 284662-16-4 (S,S)-N-bromoacetyl-bis(α-methylbenzyl)amine 
• 573970-34-0 (R,R)-(-)-bis(α-methylbenzyl)aminoacetaldehyde dimethyl acetal 
• 108462-22-2 methyl (S,S)-N,N-bis(1-phenylethyl)carbamate 
• 1020396-85-3 (S,S)-N-(2,10-dimethyl-12H-5,7-dioxa-6-phosphadibenzo[a,d]cycloocten-6-yl)bis(1-phenylethyl)amine 
• 10024-74-5 (R*,R*)-N-(1'-phenylethyl)-1-phenylethylamine 
• 21003-56-5 (1S,1'S)-bis(1-phenylethyl)amine 
• 40648-92-8 bis(1-phenylethyl)amine hydrochloride 
• 1494683-34-9 1,1-diethyl-N,N-bis((S)-1-phenylethyl)phosphinamine 
• 1494683-35-0 1,1-dibutyl-N,N-bis((S)-1-phenylethyl)phosphinamine 
• 1494683-36-1 1,1-dihexyl-N,N-bis((S)-1-phenylethyl)phosphinamine 
• 1494683-37-2 1,1-diallyl-N,N-bis((S)-1-phenylethyl)phosphinamine 
• 1494683-40-7 1,1-di(hex-1-ynyl)-N,N-bis((S)-1-phenylethyl)phosphinamine 
• 1494683-50-9 1,1-diisobutyl-N,N-bis((S)-1-phenylethyl)phosphinamine 

Relevant articles and documents

Method for synthesizing chiral phosphite ligand based on R - 2 - phenylethylamine

The invention discloses a method for synthesizing chiral phosphite ligand based on R - 2 -phenylethylamine. To the method, R - 2 -phenylethylamine is reacted with acetophenone to obtain the imine intermediate, and then is mixed with H. 2 Under

One-Pot Synthesis of Symmetrical Tertiary and Secondary Amines from Carbonyl Compounds, Ammonium Carbonate and Carbon Monoxide as a Reductant

Rh-catalyzed one-step synthesis of tertiary and secondary amines from aldehydes and ketones, ammonium carbonate serving as nitrogen source, and carbon monoxide as a reducing agent has been developed. Aliphatic and aromatic aldehydes lead to the corresponding tertiary symmetrical amines in 69–83 % yields. Aromatic and aliphatic ketones lead to the corresponding secondary symmetrical amines which were obtained in 62–79 % yields.

Preparation method of chiral amine compounds

The invention discloses a preparation method of chiral amine compounds. The preparation method of the chiral amine compounds specifically comprises the following steps: adding ketone compounds and chiral auxiliary (S)-a-phenylethylamine or (R)-a-phenylethylamine to an organic solvent to prepare an imine intermediate under the action of a large-steric-hindrance boron catalyst and a water removing agent; adding a reducing agent to the imine intermediate without separation and purification, and preparing the chiral amine compounds with a one-pot method. By calculation, the product yield is 81%-96%, and the highest de value can reach 99%. Compared with the prior art, the use amount of the large-steric-hindrance boron catalyst in the method can be reduced to 0.1 mol%, use of the equivalent metal catalyst is avoided from the source, and the method has the characteristics of being simple to operate, mild in reaction condition, wide in substrate applicability, environmental friendly and the like, and has better application value and potential economic and social benefits.