23300-99-4

Basic information

• Product Name: 1H-Indazole, 1-[(4-methylphenyl)sulfonyl]-
• Synonyms: 1-tosyl-1H-indazole;1-Tosyl-indazol;1-tosylindazole
• CAS NO: 23300-99-4
• Molecular Formula: C14H12N2O2S
• Molecular Weight: 272.327
• Mol File: 23300-99-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Indazole, 1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole, 1-[(4-methylphenyl)sulfonyl]-(23300-99-4)
• EPA Substance Registry System: 1H-Indazole, 1-[(4-methylphenyl)sulfonyl]-(23300-99-4)

Safety Data

• Hazardous Substances Data: 23300-99-4(Hazardous Substances Data)

Upstream product

• 271-44-3 benzimidazole 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 
• 271-42-1 2H-indazole 
• 98-59-9 p-toluenesulfonyl chloride 
• 1228681-08-0 (E)-N'-(2-chlorobenzylidene)-4-methylbenzenesulfonohydrazide 
• 158918-49-1 N’-(2-bromobenzylidene)-4-methylbenzenesulfonohydrazide 
• 23300-97-2 2-tosyl-2H-indazole 
• 107135-19-3 N’-(2-chlorobenzylidene)-4-methylbenzenesulfonohydrazide 
• 85865-05-0 N’-(2-iodobenzylidene)-4-methylbenzenesulfonohydrazide 

Downstream Products

• 4838-00-0 2-methyl-2H-indazole 
• 13436-48-1 1-methyl-1H-indazole 
• 271-44-3 benzimidazole 
• 74897-45-3 2-acetyl-3-amino-N-tosylindole 
• 74897-46-4 3-amino-1-(p-tosyl)indole-2-carbonitrile 
• 80289-14-1 5,11-Dihydro-11-oxo-10-tosyl-10H-indolo<3,2-b>chinolin 
• 31659-28-6 N-(2-Cyanophenyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Selective N1-Acylation of Indazoles with Acid Anhydrides Using an Electrochemical Approach

An electrochemical synthesis method for the selective N1-acylation of indazoles has been developed. This "anion pool" approach electrochemically reduces indazole molecules generating indazole anions and H2. Acid anhydrides are then introduced to the solution resulting in selective acylation of the N1-position of the indazoles. This procedure can also be applied to the acylation of benzimidazoles and indoles. The reaction can also be performed using a 9 V battery without loss of reaction efficiency.

Copper-Catalyzed Isomerization and Cyclization of E/Z-o-Haloaryl N-Sulfonylhydrazones: Convenient Access to 1H-Indazoles

The isomerization of the C=N double bond in hydrazones has drawn considerable attention because of its potential for application in a broad range of chemical transformations. Generally, this isomerization can be realized either photochemically or thermall

Copper(I) Oxide-Mediated Cyclization of o-Haloaryl N-Tosylhydrazones: Efficient Synthesis of Indazoles

An efficient synthesis of indazoles from readily accessible E/Z mixtures of o-haloaryl N-tosylhydrazones has been developed. The thermo-induced isomerization of N-tosylhydrazones is discussed. A series of valuable indazole derivatives are prepared in good yields, and the method has been successfully applied to the synthesis of the bioactive compounds, lonidamine, AF-2785, axitinib, YC-1 and YD-3.