233281-32-8

Basic information

• Product Name: N-(9-fluorenylmethyloxycarbonyl)alanine 3,4,5-tris(octadecyloxy)benzyl ester
• Synonyms: N-(9-fluorenylmethyloxycarbonyl)alanine 3,4,5-tris(octadecyloxy)benzyl ester
• CAS NO: 233281-32-8
• Molecular Weight: 1206.91
• Mol File: 233281-32-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(9-fluorenylmethyloxycarbonyl)alanine 3,4,5-tris(octadecyloxy)benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(9-fluorenylmethyloxycarbonyl)alanine 3,4,5-tris(octadecyloxy)benzyl ester(233281-32-8)
• EPA Substance Registry System: N-(9-fluorenylmethyloxycarbonyl)alanine 3,4,5-tris(octadecyloxy)benzyl ester(233281-32-8)

Safety Data

• Hazardous Substances Data: 233281-32-8(Hazardous Substances Data)

Upstream product

• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 233281-31-7 (3,4,5-trioctadecyloxyphenyl)methan-1-ol 
• 99-24-1 methyl galloate 
• 188685-33-8 methyl [3,4,5-tris(n-octadecan-1-yloxy)]benzoate 
• 149-91-7 3,4,5-trihydroxybenzoic acid 

Downstream Products

• 233281-34-0 N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester 
• 233281-37-3 phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester 
• 233281-31-7 (3,4,5-trioctadecyloxyphenyl)methan-1-ol 
• 256927-09-0 5-(chloromethyl)-1,2,3-tris(octadecyloxy)benzene 
• 233281-33-9 alanine 3,4,5-tris(octadecyloxy)benzyl ester 
• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 955095-33-7 5-(bromomethyl)-1,2,3-tris(octadecyloxy)benzene 
• 56-41-7 L-alanin 

Relevant articles and documents

A novel protecting group for constructing combinatorial peptide libraries

3,4,5-Tris(octadecyloxy)benzyl alcohol, HO-Bzl(OC18)3, was prepared from gallic acid and stearyl bromide. Using conventional step-wise elongation, N,C-protected peptides, Fmoc - AAn - ... - AA1 - OBzl(OC18)3, were synthesized. The substituted benzyl esters were selectively cleaved by a treatment with 4 M hydrogen chloride in ethyl acetate to give Fmoc - AAn - ... - AA1 - OH and HO - Bzl(OC18)3. Thus, the substituted benzyl group is effective for the protection of C-terminal carboxyl groups in liquid-phase peptide synthesis. Because the substituted benzyl group has a moderately high molecular weight, Fmoc - AAn - ... - AA1 - OBzl(OC18)3 can be easily purified by size-exclusion chromatography; all protected peptides are eluted in the void fraction of a Sephadex LH-20 gel-filtration column. The combination of the carboxyl-protecting group Bzl(OC18)3 with simple purification by the gel-filtration gives a novel route for constructing combinatorial peptide libraries in the solution phase.