23349-82-8

Upstream product

• 598-94-7 1,1-Dimethylurea 
• 131543-46-9 Glyoxal 
• 96-31-1 N,N'-Dimethylurea 
• 44307-07-5 glyoxal bis-hydrate 

Downstream Products

• 185011-07-8 1,3-dimethyl-4-(p-tolylsulfonyl)-2-imidazolinone 
• 1255948-99-2 (E)-4-(benzylideneamino)-1,3-dimethyl-5-thioxohexahydroimidazo[4,5-d]imidazol-2(1H)-one 

Relevant academic research and scientific papers

New Synthesis of 2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione Using Etidronic Acid as a “Green” Catalyst

Abstract: A new method has been developed for the synthesis of2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione in 62% yieldusing etidronic acid [1-hydroxyethane-1,1-diylbis(phosphonic acid), HEDP] as a“green” catalyst. A plausible stepwise mechanism of the reaction has beenproposed and partially confirmed by NMR data and studying model processes. Theeffects of the reaction medium and HEDP on particular species involved in thereaction, namely N,N′-dimethylurea, 4,5-dihydroxy-1,3-dimethylimidazolidin-2-one,and 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione, havebeen studied by 1H and 13CNMR spectroscopy in D2O, neutral and acidified solutions(acetic acid-d4), andsolutions containing 1 equiv of HEDP.

New access to thioglycolurils by condensation of 4,5-dihydroxyimidazolidin-2-ones(thiones) with HSCN

A general and highly effective protocol for the direct synthesis of mono- and dithioglycolurils containing various substituents at the 1,3-nitrogen atoms has been developed based on the condensation of easily accessible dihydroxyimidazolidin-2-ones with HSCN under mild reactions conditions.

Hydantoin-based molecular photoswitches

A new family of molecular photoswitches based on arylidenehydantoins is described together with their synthesis and photochemical and photophysical studies. A series of hydantoin derivatives have been prepared as single isomers using simple and versatile chemistry in good yields. Our studies show that the photostationary states of these compounds can be easily controlled by means of external factors, such as the light source or filters. Moreover, the detailed investigations proved that these switches are efficient (i.e., they make efficient use of the light energy, are high fatigue resistant, and are very photostable). In some cases, the switches can be completely turned on/off, a desirable feature for specific applications. A series of theoretical calculations have also been carried out to understand the photoisomerization mechanism at the molecular level.

Diastereoselective synthesis of 4,5-dihydroxyimidazolidin-2-ones (-thiones) and their structure

Studies on the synthesis of 4,5-dihydroxyimidazolidin-2-ones (-thiones) based on the condensation of ureas or thioureas with glyoxal or 1,2-dioxo-1,2-diphenylethane showed high diastereoselectivity in the formation of racemates (trans-diastereomers) of 4,5-dihydroxyimid- azolidin-2-ones (-thiones) and meso-forms (cis-diastereomers) of 4,5-dihydroxy-4,5-diphenyl-1,3- dialkylimidazolidine-2-thiones; plausible mechanisms of their formation were suggested. X-ray diffraction studies confirmed structures of diastereomers for separate examples of race-mates and meso-forms of 4,5-dihydroxyimidazolidin-2- ones (-thiones).

Dehydrogenation, oxidative denitration and ring contraction of N,N-dimethyl-5-nitrouracil by a Bacillus nitroreductase Nfr-A1

Nfr-A1, a Bacillus subtilis nitroreductase, catalyzes the nitroreduction of a large panel of aromatic and heterocyclic nitro compounds, except those belonging to nitrouracil class of molecules. Besides nitroreduction, Nfr-A1 exhibits a strong NADH oxidase activity in the presence of oxygen, leading to high concentration of H2O2 (up to 200 μM). In the presence of (N,N)-dimethyl-5-nitrouracil 1 (dim-NU), Nfr-A1 achieves the reduction of dim-NU double bond to compounds 2 and 3 and in parallel the oxidation of dim-NU to the denitrated five membered derivatives 4 and 5. The reduction is catalyzed by the reduced flavin Fl-Red and resembles those catalyzed by dihydropyrimidine dehydrogenases (DPD), during the catabolism of pyrimidines. The oxidative denitration is catalyzed in part by hydrogen peroxide generated through the NADH-oxidase activity, and certainly by the peroxyflavin intermediate Fl-OOH for the other part. The mechanisms of reaction were proposed according to experimental data and literature. These findings together with our previous results on the potential biological role of Nfr-A1, confirm the large spectrum of catalysis supported by this enzyme. The oxidative denitration is sporadically reported in literature and represents a safe and green alternative for the remediation of nitro-compounds.

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

PROCESS FOR PREPARING IMIDAZOLIDIN-2,4-DIONE COMPOUND AND METHOD FOR ACQUIRING SOLID STATE 4,5-DIHYDROXY-2-IMIDAZOLIDINONE COMPOUND

An object of the present invention is to provide an industrially suitable process for preparing an imidazolidin-2,4-dione compound which is safe, simple and easy to prepare the imidazolidin-2,4-dione compound with high yield, which is a useful compound, for example, as a material for decomposing a harmful halogenated aromatic hydrocarbon compound such as dioxin, etc., an electroless silver plating solution for electronic parts, or a diazo copying material, etc. This object can be solved by a process for preparing an imidazolidin-2,4-dione compound which comprises subjecting a 4,5-dihydroxy-2-imidazolidinone compound, (1) to dehydration reaction in the presence of an acid catalyst(s); or (2) to reaction at 100 to 300° C. Or, it can be solved by a process for preparing an imidazolidin-2,4-dione compound which comprises reacting a mixed solution of a urea compound, glyoxal, and a base at 20 to 300° C. Also, an object of the present invention is to provide a method for acquiring a 4,5-dihydroxy-2-imidazolidinone from an aqueous solution containing a 4,5-dihydroxy-2-imidazolidinone by a simple and easy method. This object can be solved by a process for acquiring a solid state 4,5-dihydroxy-2-imidazolidinone compound which comprises mixing an organic solvent with an aqueous solution containing a 4,5-dihydroxy-2-imidazolidinone compound, and subjecting the mixture to azeotropic distillation.

Synthesis of first representatives of 3,3′-bi(6,8-dialkyl-2,4-dioxa- 6,8-diazabicyclo[3.3.0]octan-7-ones)

The first representatives of 3,3′-bi(2,4-dioxa-6,8-diazabicyclo[3.3. 0]octan-7-ones) have been synthesized by a reaction of glyoxal as form of 2,2′-bi(4,5-dihydroxy-1,3-dioxalane) with N,N′-dialkylureas. Their structures have been supported by X-ray analy

Preparation of cyclic urea derivatives

Cyclic urea derivatives of the formula I in which X, X', Y, Y' and Z can have various meanings, are prepared by a) reacting a urea derivative of the formula II with a diketone of the formula III and b) hydrogenating the product from step a) in the presence of a metal-containing catalyst.