598-94-7

Basic information

• Product Name: 1,1-DIMETHYLUREA
• Synonyms: 1,1-DIMETHYLUREA;(CH3)2NCONH2;1,1-dimethyl-ure;Asym-Dimethylurea;Urea, 1,1-dimethyl-;urea,1,1-dimethyl-;N,N-Dimethylurea,98+%;Urea, N,N-dimethyl-
• CAS NO: 598-94-7
• Molecular Formula: C₃H₈N₂O
• Molecular Weight: 88.11
• EINECS: 202-498-7
• Product Categories: Intermediates
• Mol File: 598-94-7.mol
• Article Data: 22

Chemical Properties

• Melting Point: 178-183 °C(lit.)
• Boiling Point: 163.08°C (rough estimate)
• Flash Point: 32.7 °C
• Appearance: White to off-white/Crystalline Powder
• Density: 1.255
• Vapor Pressure: 9.71mmHg at 25°C
• Refractive Index: 1.4715 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: water: soluble5%, clear, colorless
• PKA: 14.73±0.50(Predicted)
• Water Solubility: Soluble
• BRN: 1740666
• CAS DataBase Reference: 1,1-DIMETHYLUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DIMETHYLUREA(598-94-7)
• EPA Substance Registry System: 1,1-DIMETHYLUREA(598-94-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: YS9867985
• TSCA: Yes
• Hazardous Substances Data: 598-94-7(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white crystalline powder

Uses

1,1-Dimethylurea (N,N-dimethylurea) has been used in the Dowex-50W ion exchange resin-promoted synthesis of N,N′-disubstituted-4-aryl-3,4-dihydropyrimidinones.

General Description

Nonlinear optical properties of 1,1-dimethylurea (N,N′ dimethylurea), have been evaluated through second-harmonic generation.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C3H8N2O/c1-5(2)3(4)6/h1-2H3,(H2,4,6)

Synthetic route

Azodicarboxamid (123-77-3) + Hexamethylphosphorous triamide (1608-26-0) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
In ethanol for 2h; Heating;	97%

NCNMe2 (1467-79-4) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
With [OsCl2(η6-p-cymene)(PMe2OH)]; water at 40℃; for 0.5h; Catalytic behavior; Mechanism; Reagent/catalyst; Temperature; Concentration; Inert atmosphere; Sealed tube;	92%
With potassium hydroxide
With sulfuric acid

potassium cyanate (590-28-3) + dimethyl amine (124-40-3) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
With hydrogenchloride In water at 20℃; for 12h; Inert atmosphere;	91%
With para-dodecylbenzenesulfonic acid In neat (no solvent) at 80℃; for 0.75h; Green chemistry;	83%
With sulfuric acid

tetrafluoroboric acid diethyl ether (67969-82-8) + F6P(1-)*C27H47Fe2N2OS2(1+) + NCNMe2 (1467-79-4) → 1,1-Dimethylurea (598-94-7) + F6P(1-)*C30H52Fe2N4S2(2+)*BF4(1-)

Conditions	Yield
In acetone at 20℃; for 2h; Inert atmosphere; Schlenk technique;	A 88% B 75%

dimethyl amine (124-40-3) + urea (57-13-6) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
With cholin chloride ZnCl2; iron oxide at 130℃; for 6h; Green chemistry;	73%
With Iron(III) nitrate nonahydrate In toluene for 16h; Reflux;

2-aminopyrazine-3-carboxamide oxime (76952-35-7) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 1,1-Dimethylurea (598-94-7) + 2-Cyano-3-<(dimethylaminomethylene)amino>pyrazine (34859-38-6)

Conditions	Yield
at 75℃; for 0.0833333h;	A 12% B 66%
at 75℃; for 0.0833333h;	A 12% B 66%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 2-(benzoylamino)pyridine-3-carboxamide oxime (112085-02-6) → 1,1-Dimethylurea (598-94-7) + 2-(benzoylamino)-3-cyanopyridine (112084-93-2)

Conditions	Yield
In chloroform for 2h; Product distribution; Heating;	A 7% B 66%

2,3,3,3-tetrachloro-2-propionitrile (94703-39-6) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
With sodium hydrogencarbonate for 1h; Heating;	39%

2-aminopyrazine-3-carboxamide oxime (76952-35-7) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 1,1-Dimethylurea (598-94-7) + 3-formylamino-1H-pyrazolo(3,4-b)pyrazine (81411-61-2) + 2-Cyano-3-<(dimethylaminomethylene)amino>pyrazine (34859-38-6)

Conditions	Yield
In toluene for 3h; Heating;	A 8% B 36% C 14%
In toluene for 6h; Product distribution; Heating; other times and temp.;	A 10% B 35% C 28%

N,N-dimethyl N'-(dimethyl-4,6 pyridyl-2)-2 phenyl-1 vinyluree (106932-14-3) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
hydrolysis;	11%

N,N,O-trimethyl-isourea (61713-36-8) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
With hydrogenchloride
With water

DL-2-azido-propionic acid dimethylamide + hexane (110-54-3) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
photochemische Zersetzung;

O-methyl N,N-dimethylthiocarbamate (16703-45-0) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
With methanol; ammonia at 100℃;

N,N,O-trimethylisourea hydrochloride → methylene chloride (74-87-3) + 1,1-Dimethylurea (598-94-7)

Conditions	Yield
beim Stehen;

diethyl imidocarbonate (2812-77-3) + dimethyl amine (124-40-3) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
at 130 - 140℃;
With water at 130 - 140℃;
With ethanol at 130 - 140℃;

nitrourea (556-89-8) + dimethyl amine (124-40-3) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
With water

allophanic acid methyl ester (761-89-7) + dimethyl amine (124-40-3) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
at 100℃;
at 120℃;

ω-methylallophanic acid methyl ester (83225-61-0) + dimethyl amine (124-40-3) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
With water at 100℃;
With ethanol at 120℃;
at 100℃;
at 120℃;

methyl isocyanate (624-83-9) + methylamine (74-89-5) → 1,1-Dimethylurea (598-94-7)

methylamine hydrochloride (593-51-1) + urea (57-13-6) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
at 160 - 170℃;

N,N-dimethyl-formamide (68-12-2, 33513-42-7) → 1,1-Dimethylurea (598-94-7)

Conditions	Yield
(i) POCl3, (ii) NH2OH; Multistep reaction;

2,4-lutidine (108-47-4) + benzonitrile (100-47-0) + N,N-Dimethylcarbamoyl chloride (79-44-7) → 1,1-Dimethylurea (598-94-7) + 2,4,6-triphenyl-1,3,5-triazine (493-77-6) + methyl-4 phenyl-7 6H naphtyridin-1,6 one-5 (106932-30-3)

Conditions	Yield
With lithium 1.) diethyl ether, reflux, 1 h, 2.) ether, reflux, 2.5 h, 3.) ether; Yield given. Multistep reaction. Yields of byproduct given;

urea (57-13-6) + N,N-dimethylformamide diethyl diacetal (1188-33-6) → 1,1-Dimethylurea (598-94-7) + N-Aminocarbonyl-N',N'-dimethyl-formamidin (83490-19-1) + 1,1-dimethyl-3-dimethylaminomethyleneurea (20353-90-6)

Conditions	Yield
at 85℃; for 3h; Yield given. Yields of byproduct given;

urea (57-13-6) + N,N-dimethylacetamide diethyl acetal (19429-85-7) → 4,6-Dimethyl-sym-triazin-2-one (30885-99-5) + 1,1-Dimethylurea (598-94-7) + 4-Dimethylamino-6-methylpyrimidin-2-one (69606-63-9)

Conditions	Yield
for 3h; Heating; Yield given;	A n/a B n/a C 0.21 g
for 3h; Heating; Yields of byproduct given;	A n/a B n/a C 0.21 g

urea (57-13-6) + N,N-dimethylacetamide diethyl acetal (19429-85-7) → 4,6-Dimethyl-sym-triazin-2-one (30885-99-5) + 1,1-Dimethylurea (598-94-7) + N-Carbamoyl-N',N'-dimethylaminoacetamidine (84690-53-9)

Conditions	Yield
In ethanol at 35 - 40℃; for 0.05h; Yield given;

3,5-dimethyl-1,3,5-oxadiazane-2,4,6-trione (36209-52-6) + water (7732-18-5) → 1,1-Dimethylurea (598-94-7)

3,5-dimethyl-1,3,5-oxadiazane-2,4,6-trione (36209-52-6) + KOH-solution → 1,1-Dimethylurea (598-94-7)

1,3-dimethyl-5-hydroxyhydantoin-5-carboxamide (87897-69-6) + aq. barium hydroxide solution → 1,1-Dimethylurea (598-94-7) + acetonedicarboxylic acid (473-90-5)

1,3-dimethylparabanic acid (5176-82-9) + aq. barium hydroxide solution → 1,1-Dimethylurea (598-94-7) + oxalic acid (144-62-7)

1,3-dimethylparabanic acid (5176-82-9) + aqueous-alcoholic KOH-solution → 1,1-Dimethylurea (598-94-7) + oxalic acid (144-62-7)

1,1-Dimethylurea (598-94-7) + phenylacetylene (536-74-3) → 1,1-dimethyl-3-[(Z)-2-phenylvinyl]urea (1095320-53-8)

Conditions	Yield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 1,4-bis(dicyclohexylphosphino)butane; ytterbium(III) triflate In water; N,N-dimethyl-formamide at 60℃; for 6h; Inert atmosphere; optical yield given as %de; stereoselective reaction;	99%
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 1,4-bis(dicyclohexylphosphino)butane; water; ytterbium(III) triflate In N,N-dimethyl-formamide at 60℃; for 6h; anti-Markovnikov hydroamidation; Inert atmosphere; optical yield given as %de; stereoselective reaction;	46%

1,1-Dimethylurea (598-94-7) + 4-methyl-benzoyl chloride (874-60-2) → 1,1-Dimethyl-3,3-bis-(4-methyl-benzoyl)-urea (104825-41-4)

Conditions	Yield
In pyridine for 24h; Ambient temperature;	98%

1,1-Dimethylurea (598-94-7) + 4-chloro-benzoyl chloride (122-01-0) → 1,1-Bis-(4-chloro-benzoyl)-3,3-dimethyl-urea (104417-74-5)

Conditions	Yield
In pyridine for 24h; Ambient temperature;	98%

1,1-Dimethylurea (598-94-7) + 4-methoxy-benzoyl chloride (100-07-2) → 1,1-Bis-(4-methoxy-benzoyl)-3,3-dimethyl-urea (104825-42-5)

Conditions	Yield
In pyridine for 24h; Ambient temperature;	97%

methycarbamoyl chloride + 1,1-Dimethylurea (598-94-7) + methyl isocyanate (624-83-9) → methylcarbamoyl chloride (6452-47-7)

Conditions	Yield
In chloroform	96.7%

N-methylene-tert-butylamine (13987-61-6) + 1,1-Dimethylurea (598-94-7) → 3-{[tert-Butyl-(3,3-dimethyl-ureidomethyl)-amino]-methyl}-1,1-dimethyl-urea (141564-68-3)

Conditions	Yield
for 4h; Heating;	95%

1,1-Dimethylurea (598-94-7) + 2,2,3,3-tetramethylcyclopropanecarbonyl chloride (24303-61-5) → 1,1,N,N-dimethyl-2,2,3,3-tetramethylcyclopropanecarbonyl urea

Conditions	Yield
In acetonitrile for 2h; Heating;	95%

[(diethylenetriamine)Pt(OH2)](CF3SO3)2 + 1,1-Dimethylurea (598-94-7) → (diethylenetriamine)(1,1-dimethylurea)platinum(II) trifluoromethanesulfonate

Conditions	Yield
In acetone stirring for 30 min at 30°C; cooling in ice; decanting; addn. of diethyl ether to soln.; drying the oily ppt. by vac. evapn.; redissolving in acetone; filtration; addn. of diethyl ether; cooling (0°C, 3 d); filtration; washing (diethyl ether); air-drying; elem. anal.;	90%

1,1-Dimethylurea (598-94-7) + 1-benzyl-3,5-dichloro-6-methylpyrazin-2(1H)-one (173200-35-6) → 3-(4-benzyl-6-chloro-5-methyl-3-oxo-3,4-dihydropyrazin-2-yl)-1,1-dimethylurea

Conditions	Yield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,2-dimethoxyethane at 80 - 100℃; Microwave irradiation;	90%

1,1-Dimethylurea (598-94-7) + E-1-(4'-methoxyphenyl)prop-1-ene (4180-23-8) → 4-(4-methoxyphenyl)-N,N,5-trimethyl-4,5-dihydrooxazol-2-amine

Conditions	Yield
With Selectfluor; lithium iodide In dichloromethane at 80℃; for 16h; diastereoselective reaction;	90%

acridine (260-94-6) + 1,1-Dimethylurea (598-94-7) → 3-(10H-acridin-9-ylidene)-1,1-dimethylurea

Conditions	Yield
Stage #1: 1,1-Dimethylurea With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; Inert atmosphere; Stage #2: acridine In dimethyl sulfoxide; mineral oil at 20℃; for 24h; Inert atmosphere;	89%

1H-tetrazole (288-94-8) + 1,1-Dimethylurea (598-94-7) + 4-methoxy-benzaldehyde (123-11-5) → C12H16N6O2

Conditions	Yield
In ethanol for 0.1h; Sonication;	89%

1,1-Dimethylurea (598-94-7) + tri-O-(tert-butyldimethylsilyl)-D-glucal (79999-47-6) → 1,1-dimethyl-3-[3,4,6-tris(O-tert-butyldimethylsilyl)-2-deoxy-2-iodo-α-D-mannopyranosyl]urea (1391998-98-3)

Conditions	Yield
With N-iodo-succinimide In propiononitrile at -78 - 20℃; for 56h; Inert atmosphere;	88%

1H-tetrazole (288-94-8) + 1,1-Dimethylurea (598-94-7) + 4-hydroxy-benzaldehyde (123-08-0) → C11H14N6O2

Conditions	Yield
In ethanol for 0.1h; Sonication;	88%

1,1-Dimethylurea (598-94-7) + benzoyl chloride (98-88-4) → 1,1-Dibenzoyl-3,3-dimethyl-harnstoff (104417-73-4)

Conditions	Yield
In pyridine for 24h; Ambient temperature;	86%

1,1-Dimethylurea (598-94-7) + 2-nitrobenzyl chloride (610-14-0) → 1,1-Dimethyl-3,3-bis-(2-nitro-benzoyl)-urea (104417-76-7)

Conditions	Yield
In pyridine for 24h; Ambient temperature;	86%

1,1-Dimethylurea (598-94-7) + trichloromethyl chloroformate (503-38-8) → tetramethylcarbamoylurea (7767-31-9)

Conditions	Yield
In acetonitrile Ambient temperature;	86%

sodium dithionate + trifluoromethanesulfonatopentaamminecobalt(III) trifluoromethanesulfonate (115245-01-7) + 1,1-Dimethylurea (598-94-7) → 2(NH3)5CoOC(NH2)(N(CH3)2)(3+)*3S2O6(2-)*3H2O={(NH3)5CoOC(NH2)(N(CH3)2)}2(S2O6)3*3H2O

Conditions	Yield
In water; acetone to N,N-dimethylurea in acetone (Co(NH3)5OSO2CF3)(CF3SO3)2 added and mixt. warmed (60°C) for 10 min, cooled to room temp. and poured intoEt2O, mixt. stirred for 10 min, residue redissolved in ice water and added to aq. soln. Na2S2O6; mixt. cooled (<5°C) for 15 min, crystals collected, washed with ice water, ethanol and ether and dried over P2O5; elem. anal.;	86%
In acetone Co-complex added to a soln. of urea; mixture warmed at 60°C for 15 min;; poured into butan-2-ol, ether added, stirred, solid dissolved in ice-water, filtered, treated with aq. Na2S2O6 at 20°C; cooled and stirred, crystals washed with ice-water, EtOH, ether, air-dried;;	85%

1,1-Dimethylurea (598-94-7) + 3-((2-chloropyridin-4-yl)oxy)-2-methyl-6-nitropyridine → 1,1-dimethyl-3-(4-((2-methyl-6-nitropyridin-3-yl)oxy)pyridin-2-yl)urea

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; Concentration; Inert atmosphere;	86%

dioxouranium(VI) perchlorate hydrate + 1,1-Dimethylurea (598-94-7) → UO2(N(CH3)2CONH2)5(2+)*2ClO4(1-)

Conditions	Yield
In ethanol dissolving of uranium salt in a mixture of EtOH/triethylorthoformate, heating at 323 K for 90 min with stirring, addn. of urea, further heating for 90 min; cooling to room temp., filtn., addn. of ether to the filtrate with stirring, filtn., washing with ether, drying under N2, elem. anal.;	85%

1,1-Dimethylurea (598-94-7) + chloro(chlorosulfanyl)methanone (2757-23-5) → 5-(N,N-dimethylamino)-1,3,4-oxathiadiazol-2-one (90545-89-4)

Conditions	Yield
In acetonitrile at 20℃; for 20h;	84%
In acetonitrile for 1h;	74.5%
In acetonitrile at 20℃;	70%
In methanol; hexane; dichloromethane; acetonitrile

1,1-Dimethylurea (598-94-7) + 4-tert-Butylstyrene (1746-23-2) → 4-(4-(tert-butyl)phenyl)-N,N-dimethyl-4,5-dihydrooxazol-2-amine

Conditions	Yield
With Selectfluor; lithium iodide In dichloromethane at 80℃; for 16h; regioselective reaction;	84%

1,1-Dimethylurea (598-94-7) + 2,4,6-Trinitrophenol (88-89-1) → picric acid ; picrate of N,N-dimethyl-urea (87448-62-2)

Conditions	Yield
	83%

1,1-Dimethylurea (598-94-7) → 4,5-dihydroxy-1,3-dimethylimidazolidin-2-one (3923-79-3)

Conditions	Yield
In methanol	83%

1,1-Dimethylurea (598-94-7) + 3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl bis(trifluoromethanesulfonate) (1195931-66-8) → 1,1'-(3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl)bis(3,3-dimethylurea)

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 18h; Buchwald-Hartwig cross coupling; Inert atmosphere;	83%

1,1-Dimethylurea (598-94-7) + 3-formyl-2-(N-methyl)allylaminopyridine → N,N,9-trimethyl-6,7,8,9-tetrahydro-5H-5,8-epiminopyrido[2,3-b]azepine-10-carboxamide

Conditions	Yield
With toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene Reflux;	83%

Upstream product

• 1467-79-4 NCNMe₂ 
• 2812-77-3 diethyl imidocarbonate 
• 124-40-3 dimethyl amine 
• 590-28-3 potassium cyanate 
• 624-83-9 methyl isocyanate 
• 74-89-5 methylamine 
• 68-12-2 N,N-dimethyl-formamide 
• 108-47-4 2,4-lutidine 
• 100-47-0 benzonitrile 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 
• 57-13-6 urea 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 19429-85-7 N,N-dimethylacetamide diethyl acetal 
• 21802-62-0 4-hydroxy-1,3-dimethyl-2,5-dioxo-imidazolidine-4-carboxylic acid ethylamide 

Downstream Products

• 103-81-1 Benzeneacetamide 
• 15719-64-9 methylammonium carbonate 
• 99114-96-2 N,N'-bis-dimethylcarbamoyl-oxalamide 
• 19039-41-9 7,9-dimethyluric acid 
• 53376-31-1 N,N-dimethyl-N'-(2,2,2-trichloro-1-hydroxy-ethyl)-urea 
• 127-19-5 N,N-dimethyl acetamide 
• 108-80-5 isocyanuric acid 
• 39615-79-7 1-(2-cyanoacetyl)-1,3-dimethyl-urea 
• 22496-14-6 1,3-dimethyl-4,5-diphenyl-1,3-dihydro-2H-imidazol-2-one 
• 60-35-5 acetamide 
• 79-16-3 N-methyl-acetamide 
• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 6456-01-5 1,3-dimethyl-5,5-diphenylhydantoin 
• 573-34-2 2,4,5-triphenyloxazole 

Relevant articles and documents

Catalytic hydration of cyanamides with phosphinous acid-based ruthenium(ii) and osmium(ii) complexes: scope and mechanistic insights

The synthesis of a large variety of ureas R1R2NC(O)NH2 (R1 and R2 = alkyl, aryl or H; 26 examples) was successfully accomplished by hydration of the corresponding cyanamides R1R2NCN using the phosphinous acid-based complexes [MCl2(η6-p-cymene)(PMe2OH)] (M = Ru (1), Os (2)) as catalysts. The reactions proceeded cleanly under mild conditions (40-70 °C), in the absence of any additive, employing low metal loadings (1 molpercent) and water as the sole solvent. In almost all the cases, the osmium complex 2 featured a superior reactivity in comparison to that of its ruthenium counterpart 1. In addition, for both catalysts, the reaction rates observed for the hydration of the cyanamide substrates were remarkably faster than those involving classical aliphatic and aromatic nitriles. Computational studies allowed us to rationalize all these trends. Thus, the calculations indicated that the presence of a nitrogen atom directly linked to the CN bond depopulates electronically the nitrile carbon by inductive effect when coordinated to the metal center, thus favouring the intramolecular nucleophilic attack of the OH group of the phosphinous acid ligand to this carbon. On the other hand, the higher reactivity of Os vs. Ru seems to be related with the lower ring strain on the incipient metallacycle that starts to form in the transition state associated with this key step in the catalytic cycle. Indirect experimental evidence of the generation of the metallacyclic intermediates was obtained by studying the reactivity of [RuCl2(η6-p-cymene)(PMe2OH)] (1) towards dimethylcyanamide in methanol and ethanol. The reactions afforded compounds [RuCl(η6-p-cymene)(PMe2OR)(NCNMe2)][SbF6] (R = Me (5a), Et (5b)), resulting from the alcoholysis of the metallacycle, which could be characterized by single-crystal X-ray diffraction. This journal is

Preparation technical method of high purity 1, 1-dimethylurea

The invention discloses a preparation method of high purity 1, 1-dimethylurea. 1, 1-dimethylurea is a medical and pesticide intermediate and an important synthesis raw material of rocket fuel 1, 1-dimethylhydrazine which is used in national defense chemistry. According to the preparation method, a hydrazine type remover and a reaction controlling are added to avoid problems in the prior art that influences are caused by hydrazine type compound impurities, and generation of by-products is caused because of the instability of the reactants, a certain amount of a weak alkali oxidizing agent is added, and then routine cooling crystallization, centrifugation, recrystallization, and vacuum drying are carried out so as to obtain the high purify intermediate 1, 1-dimethylurea crystalline powder contains no high toxicity residue, all impurity sources are controlled and eliminated, commercial large scale product is realized, cost is reduced, and equipment is simple.