233608-13-4

Basic information

• Product Name: 1-(4-METHOXY-PHENYL)-PROPYLAMINEHYDROCHLORIDE
• Synonyms: 1-(4-METHOXY-PHENYL)-PROPYLAMINEHYDROCHLORIDE;1-(4-METHOXYPHENYL)PROPAN-1-AMINE HYDROCHLORIDE;1-(4-METHOXYPHENYL)PROPAN-1-AMINE HCL
• CAS NO: 233608-13-4
• Molecular Formula: C10H16ClNO
• Molecular Weight: 201.69
• Mol File: 233608-13-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-METHOXY-PHENYL)-PROPYLAMINEHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-PHENYL)-PROPYLAMINEHYDROCHLORIDE(233608-13-4)
• EPA Substance Registry System: 1-(4-METHOXY-PHENYL)-PROPYLAMINEHYDROCHLORIDE(233608-13-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 233608-13-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-METHOXY-PHENYL)-PROPYLAMINEHYDROCHLORIDE is used as a key intermediate in the synthesis of various pharmaceuticals and research chemicals. Its versatile chemical structure allows for the development of new compounds with potential therapeutic applications.
Used in Psychoactive Substance Research:
In the field of psychopharmacology, 1-(4-METHOXY-PHENYL)-PROPYLAMINEHYDROCHLORIDE is used as a research compound for studying its potential as a psychoactive substance. It may have implications in the treatment of mood and anxiety disorders, although further research is necessary to fully understand its effects and safety profile.
Used in Mood and Anxiety Disorder Treatment:
1-(4-METHOXY-PHENYL)-PROPYLAMINEHYDROCHLORIDE is being explored for its potential use in the treatment of mood and anxiety disorders. Its psychoactive properties may offer new avenues for therapeutic intervention, although it should be handled with care and used only by trained professionals in a controlled laboratory setting.

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 123-11-5 4-methoxy-benzaldehyde 
• 244092-54-4 (R,E)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide 
• 121-97-1 4-Methoxypropiophenone 
• 83948-35-0 1-(4-methoxyphenyl)propan-1-amine 
• 24316-59-4 p-Methoxypropiophenone oxime 
• 180399-97-7 [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester 

Relevant articles and documents

Asymmetric synthesis of chiral amines by highly diastereoselective 1,2- additions of organometallic reagents to N-tert-butanesulfinyl imines

High yielding and highly diastereoselective methods for 1,2-additions of organometallic reagents to N-tert-butanesulfinyl aldimines (2) and N-tert- butanesulfinyl kerimines (3) are described. The additions of alkyl, aryl, alkenyl, and allyl carbanions to a diverse set of imines with different steric and electronic properties are demonstrated. Acidic methanolysis of the sulfinamide products (4 and 6) delivers highly enantioenriched α-branched and α,α-dibranched amines. Since a broad range of sulfinyl imines are easily accessible from aldehydes and ketones, a wide variety of enantioentriched amines may be prepared.

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders

Herein, we describe the discovery of a potent, selective, brain-penetrating, in vivo active phosphodiesterase (PDE) 2A inhibitor lead series. To identify high-quality leads suitable for optimization and enable validation of the physiological function of PDE2A in vivo, structural modifications of the high-throughput screening hit 18 were performed. Our lead generation efforts revealed three key potency-enhancing functionalities with minimal increases in molecular weight (MW) and no change in topological polar surface area (TPSA). Combining these structural elements led to the identification of 6-methyl-N-((1R)-1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (38a), a molecule with the desired balance of preclinical properties. Further characterization by cocrystal structure analysis of 38a bound to PDE2A uncovered a unique binding mode and provided insights into its observed potency and PDE selectivity. Compound 38a significantly elevated 3′,5′-cyclic guanosine monophosphate (cGMP) levels in mouse brain following oral administration, thus validating this compound as a useful pharmacological tool and an attractive lead for future optimization.

NITROGENATED HETEROCYCLIC COMPOUND

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

APPLICATIONS OF N6-SUBSTITUTED ADENOSINE DERIVATIVE AND N6-SUBSTITUTED ADENINE DERIVATIVE TO CALMING, HYPNOSES, CONVULSION RESISTANCE, EPILEPTIC RESISTANCE, PARKINSON DISEASE RESISTANCE, AND DEMENTIA PREVENTION AND TREATMENT

PROBLEM TO BE SOLVED: To prepare analgesics, hypnotic agents, anticonvulsant agents, antiepileptics, antiparkinson drugs, dementia prophylactics, and health care food. SOLUTION: The present invention relates to an N6-substituted adenosine derivative and an N6-substituted adenine derivative selected from the group consisting of specific compounds. The present invention also relates to a pharmaceutical composition at least comprising a therapeutically effective amount of the compounds and a pharmaceutically acceptable carrier. The invention further relates to the compounds used in preparation of analgesics, hypnotic agents, anticonvulsant agents, antiepileptics, antiparkinson drugs, dementia prophylactics, and health care food. COPYRIGHT: (C)2016,JPO&INPIT

N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF

The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF

The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

Synthesis of α-arylalkylamines by addition of Grignard reagents to N- (diethoxyphosphoryl)aldimines

Addition of organomagnesium bromides to N-(diethoxyphosphoryl) aldimines 1 carded out in tetrahydrofuran at 20-25°C affords diethyl N-alkyl- phosphoramidates 2a-w in high yields and spectroscopic purity. Deprotection of the latent amino groups in 2 results in the formation of α-arylalkylamine hydrochlorides 3a-w.