23386-72-3

Upstream product

• 1123-27-9 1-(1-hydroxycyclohexyl)ethan-1-one 
• 17962-22-0 1-((trimethylsilyl)ethynyl)cyclohexanol 
• 1123-28-0 1-hydroxy-cyclohexanecarboxylic acid 
• 78-27-3 1-Ethynylcyclohexan-1-ol 
• 23386-81-4 4-[1-Bromo-meth-(Z)-ylidene]-1,3-dioxa-spiro[4.5]decane 

Downstream Products

• 23863-00-5 1-(1-hydroxy-cyclohexyl)-2-morpholin-4-yl-ethanone 
• 112070-81-2 2-acetoxy-1-(1-hydroxy-cyclohexyl)-ethanone 
• 131731-88-9 1-[2-(1-hydroxy-cyclohexyl)-2-oxo-ethyl]-pyridinium; bromide 

Relevant academic research and scientific papers

Hydroxyketones in the thiadiazine cycle formation

Cyclocondensation of 1-hydroxyketones with thiosemicarbazide resulted in thiadiazines. Nitrate ester of 1-hydroxyketone reacted under similar conditions to give the corresponding thiosemicarbazone. In the case of bromoacetyl-substituted nitrate ester of 1-hydroxyketone, condensation proceeded via intramolecular reaction between the thiol and bromomethyl groups.

Synthesis of Imidazo[1,2-a]pyridines and Imidazo[2,1-b]thiazoles Attached to a Cycloalkyl or Saturated Heterocycle Containing a Tertiary Hydroxy Substitution

A new method has been developed for the synthesis of imidazo[1,2-a]pyridines, imidazo[2,1-b]thiazoles, and benzo[d]imidazo[2,1-b]thiazoles attached to a cycloalkyl or saturated heterocycle containing a tertiary hydroxy substitution. Readily available substituted 2-aminopyridines, 2-aminothiazoles, and 2-aminobenzothiazoles were treated with bromohydroxycycloalkyl ethanones to afford the desired products in good yields.