23389-74-4

Usage

Safety Profile

A poison by intraperitoneal route. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx.

InChI:InChI=1/C11H15NO/c1-2-3-4-5-11(13)10-6-8-12-9-7-10/h6-9H,2-5H2,1H3

Upstream product

• 1570-45-2 isonicotinic acid ethylester 
• 23708-48-7 pentamethylenebis(magnesium bromide) 
• 872-85-5 pyridine-4-carbaldehyde 
• 109-67-1 1-penten 
• 693-25-4 n-pentylmagnesium bromide 
• 23396-22-7 α-pentyl-4-pyridinemethanol 

Relevant academic research and scientific papers

Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones

Context and objective: The present study is to elucidate the comparative inhibition of tetrameric carbonyl reductase (TCBR) activity by alkyl 4-pyridyl ketones, and to characterize its substrate-binding domain. Materials and methods: The inhibitory effect

The anion of 3-methyl-2-pyridin-4-yl-1,3-oxazine

n-Butyllithium at -78°C readily abstracts the methine proton from the title compound. The anion reacts efficiently with a range of electrophiles to provide 4-pyridyl ketones upon acid hydrolysis.

Hydroacylation of 1-alkene with heteroaromatic aldehyde by Rh(I) and additives

Hydroacylation of 1-alkene with a heteroaromatic aldehyde such as pyridinecarboxaldehyde, thiophenecarboxaldehyde and furfural derivatives under cocatalyst of Wilkinson's complex and 2-amino-3-picoline gave poor yield of hydroacylated product. The addition of a catalytic amount of bis(cyclopentadienyl)zirconium dichloride or bis(cyclopentadienyl)titanium dichloride as an additive dramatically increased the yield of the hydroacylated ketone product.

STERIC EFFECTS IN THE REACTION OF DI(BROMOMAGNESIO)ALKANES WITH CARBOXYLIC ESTERS

Largely different product distributions were observed on the action of various carboxylic esters with 1,4-di(bromomagnesio)butane and its homologue 1,5-di(bromomagnesio)pentane.The much larger yields of reduction product with the latter are the evidence for the structural geometric requirements for the annelation step.