58879-07-5

Basic information

• Product Name: 1-benzyl-3-phenylpiperidin-3-ol
• CAS NO: 58879-07-5
• Molecular Formula: C₁₈H₂₁NO
• Molecular Weight: 267.3654
• Mol File: 58879-07-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 408.5°C at 760 mmHg
• Flash Point: 113.1°C
• Density: 1.135g/cm³
• Vapor Pressure: 2.09E-07mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 1-benzyl-3-phenylpiperidin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-phenylpiperidin-3-ol(58879-07-5)
• EPA Substance Registry System: 1-benzyl-3-phenylpiperidin-3-ol(58879-07-5)

Safety Data

• Hazardous Substances Data: 58879-07-5(Hazardous Substances Data)

Usage

Class

Piperidinols

Derivative

Piperidine

Structural similarities

Opioids

Potential pharmaceutical properties

Analgesic, sedative, treatment of opioid addiction

Studied in

Animal models

Promise as a potential medication

Pain management, addiction treatment

Additional research needed

To fully understand its pharmacological properties and potential therapeutic uses.

Upstream product

• 40114-49-6 1-benzyl-3-piperidone 
• 100-59-4 phenylmagnesium chloride 
• 100-44-7 benzyl chloride 
• 6859-99-0 3-hydroxypiperazine 
• 100-58-3 phenylmagnesium bromide 
• 39514-19-7 ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate 
• 14813-01-5 1-benzyl-3-hydroxypiperidine 
• 63876-32-4 4-[benzyl(ethoxycarbonylmethyl)amino]butyric acid ethyl ester 

Downstream Products

• 23396-50-1 3-hydroxy-3-phenylpiperidine 
• 1335523-82-4 4-(3S-piperidine-3-yl)bromobenzene 
• 59349-71-2 (S)-3-phenylpiperidine hydrochloride 
• 3979-67-7 N-benzyl-3-phenylpiperidine 
• 1196713-21-9 (3S)-3-(4-aminophenyl)piperidine 
• 430461-56-6 (R)-3-phenyl piperidine 
• 3973-62-4 3-phenylpiperidine 
• 188024-86-4 (3,4-Dinitro-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-76-2 (3-Hydroxy-3-phenyl-piperidin-1-yl)-(4-nitro-phenyl)-methanone 
• 188024-80-8 Biphenyl-4-yl-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-78-4 (3,4-Dibromo-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-77-3 (3,5-Dichloro-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-75-1 (3,4-Dichloro-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 

Relevant articles and documents

Synthesis method for (R)-3-phenylpiperidine or/and (S)-3-phenylpiperidine and synthesis method for chiral intermediate of niraparib

The invention belongs to the technical field of organic synthesis. The synthesis method firstly provided by the invention takes benzyl-4-oxopiperidine as a starting material, and the starting materialis subjected to Grignard reaction, elimination reaction, hydrogenation reduction reaction and chiral resolution in sequence to successfully obtain a target product (R)-3-phenylpiperidine or/ and (S)-3-phenylpiperidine. The synthesis method sencondly provided by the invention takes the same starting raw material for Grignard reaction, organic silicon reagent is used for removing a hydroxide radical, and benzyl is removed by catalytic hydrogenation reaction; finally, the chiral resolution is carried out to obtain a target product. The (S)-3-phenylpiperidine can be synthesized according to the synthesis method. (S)-3-p-aminosalicylic phenylpiperidine can be synthesized according to the third aspect; or according to the fourth aspect, (S)-3-p-bromophenyl piperidine is synthesized to serve asthe key intermediate for preparing the niraparib. According to the synthesis method for (R)-3-phenylpiperidine or/ and (S)-3-phenylpiperidine and the synthesis method for chiral intermediate of niraparib, production cost is obviously lowered, and the synthesis methods are favorable for the large-scale industrial production of a niraparib medicine.

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists

A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed.

An efficient synthesis of N-aroyl-3-phenyltetrahydropyridines

N-Aroyl-3-phenyltetrahydropyridines were conveniently synthesized by dehydration of N-aroyl-3-hydroxy-3-phenylpiperidines with toluenesulfonic acid on silica gel as a dehydration reagent.