23399-88-4

Usage

Uses

Used in Chemical Synthesis:
2,4,6-Trichlorophenetole is used as an intermediate in the chemical synthesis industry for the production of other chemicals. Its role in synthesis is crucial for creating a range of compounds that have various applications across different sectors.
Used as a Solvent:
In the chemical industry, 2,4,6-trichlorophenetole is utilized as a solvent due to its ability to dissolve a wide range of substances. Its solvent properties make it suitable for use in various chemical processes, facilitating reactions and improving the efficiency of production.
Used in Fragrance Industry:
2,4,6-Trichlorophenetole is used as a fragrance ingredient in the consumer products industry, capitalizing on its strong, sweet, floral scent. It contributes to the creation of perfumes, colognes, and other scented products that are part of everyday life.
Used in Consumer Products:
Beyond its use in fragrances, 2,4,6-trichlorophenetole is also incorporated into other consumer products for its scent. This includes a variety of household and personal care items where a pleasant aroma is desired.
Environmental and Health Considerations:
Given the compound's potential hazards to human health and the environment, it is imperative that industries using 2,4,6-trichlorophenetole adhere to strict handling and disposal protocols. This ensures minimal exposure and mitigates the risks associated with its use.

InChI:InChI=1/C8H7Cl3O/c1-2-12-8-6(10)3-5(9)4-7(8)11/h3-4H,2H2,1H3

Upstream product

• 60-29-7 diethyl ether 
• 2678-54-8 ketene diethyl acetal 
• 88-06-2 2,4,6-Trichlorophenol 
• 75-03-6 ethyl iodide 
• 1569262-64-1 ethyl N-tert-butyl-4-nitrobenzenesulfonimidate 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 622-61-7 1-chloro-4-ethoxybenzene 

Relevant academic research and scientific papers

Accurate determination of 2,4,6-trichloroanisole in wines at low parts per trillion by solid-phase microextraction followed by GC-ECD

A headspace solid-phase microextraction (HS-SPME) procedure at 30 °C with a 100 μm PDMS fiber of a saturated NaCl solution stirred at 1100 rpm combined to GC-ECD for the 2,4,6-trichloroanisol (TCA) determination in wines has been developed. Due to the matrix complexity and ethanol absorption into the fiber, the internal standard selection was crucial to obtain unbiased results. Thus, matrix effects were observed when analyzing different types of Spanish wines (white, early, and vintage red wines) spiked with TCA at low concentration levels (i.e., -1). In contrast, the use of 2,4,6-tribromoanisole (TBA) as internal standard overcame these matrix effects, whereas the use of 2,4,6-trichlorophenyl ethyl ether led to inconsistent results. The developed HS-SPME-GC-ECD methodology reaches a limit of quantitation for TCA in wine within 2.9-18 ng L-1, with a relative standard deviation of 2.5-13.4%, depending on the TCA concentration level and wine characteristics. This analytical method is comparable to the existing methodologies based on HS-SPME followed by GC-MS in terms of accuracy, precision, length of determination, and length of quantification; however, analysis cost is reduced.

SNAAP sulfonimidate alkylating agent for acids, alcohols, and phenols 1

Stable, crystalline ethyl N-tert-butyl-4-nitrobenzenesulfonimidate has been prepared in high yield by direct O-ethylation of N-tert-butyl-4- nitrobenzenesulfonamide with iodoethane and silver(I) oxide in dichloromethane. This sulfonimidate directly ethylates various acids to esters; the stronger the acid, the faster it alkylates and in higher yield. It readily ethylates alcohols and phenols to ethers at room temperature in the presence of tetrafluoroboric acid catalyst without molecular rearrangements or racemization. We have defined these reactions as SNAAP alkylations: [substitution, nucleophilic of acids, alcohols and phenols]. The hard sulfonimidate alkylating agent is chemoselective, preferring oxygen > nitrogen > sulfur. The sulfonamide byproduct of alkylation is readily recycled to the sulfonimidate. Georg Thieme Verlag Stuttgart . New York.

Formation of Nonaromatic Products in the Chlorination of Simple Substituted Aromatic Ethers

The neat chlorination of 4-chloroanisole produces 1,3,4,5,6-pentachloro-4-methoxycyclohexene in 35percent yield.Mono- and dichlorinated anisoles and a variety of simple substituted anisoles were chlorinated to determine the generality of nonaromatic product formation. 3,4-Dichloroanisole, 4-fluoroanisole, 4-bromoanisole, 4-methylanisole, and 4-chlorophenetole form similar products based on their spectral properties.These products are proposed to form by a cis-1,2-chlorine addition followed by rapid cis-1,4 chlorine addition.On the basis of the NMR data, a predominate configuration is proposed.