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CAS

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2340-21-8

1-Phenyl-3-(2,2,2-trifluoroethyl)urea is an organic compound with the molecular formula C9H8F3N2O. It is a derivative of urea, featuring a phenyl group attached to the nitrogen atom and a 2,2,2-trifluoroethyl group attached to the other nitrogen atom. This chemical is primarily used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and reactivity. The presence of the trifluoroethyl group imparts specific properties to the molecule, such as increased lipophilicity and metabolic stability, which can be beneficial in drug design. The compound is typically synthesized through the reaction of phenyl isocyanate with 2,2,2-trifluoroethanol, followed by the formation of the urea linkage. It is an example of how fluorination can significantly alter the properties of a molecule, making it a valuable intermediate in the development of new chemical entities.

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  • 2340-21-8 Structure

  • Basic information

    1. Product Name: 1-phenyl-3-(2,2,2-trifluoroethyl)urea
    2. Synonyms: 1-phenyl-3-(2,2,2-trifluoroethyl)urea
    3. CAS NO:2340-21-8
    4. Molecular Formula:
    5. Molecular Weight: 218.178
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2340-21-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-phenyl-3-(2,2,2-trifluoroethyl)urea(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-phenyl-3-(2,2,2-trifluoroethyl)urea(2340-21-8)
    11. EPA Substance Registry System: 1-phenyl-3-(2,2,2-trifluoroethyl)urea(2340-21-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2340-21-8(Hazardous Substances Data)

2340-21-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2340-21-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,4 and 0 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2340-21:
(6*2)+(5*3)+(4*4)+(3*0)+(2*2)+(1*1)=48
48 % 10 = 8
So 2340-21-8 is a valid CAS Registry Number.

2340-21-8Downstream Products

2340-21-8Relevant articles and documents

Synthesis of 3,3,3-trifluoroethyl isocyanate, carbamate and ureas. Anticancer activity evaluation of N-(3,3,3-trifluoroethyl)-N′-substituted ureas

Luzina, Elena L.,Popov, Anatoliy V.

, p. 82 - 88 (2015)

A new method is described for producing 3,3,3-trifluoroethyl isocyanate from perfluoroisobutene (PFIB). Isocyanate was used for synthesis of carbamates and ureas. A series of trifluoroethyl-substituted ureas has been tested in the National Cancer Institute (NCI, Bethesda, USA) by the NCI-60 DTP Human Tumor Cell Line Screening Program at a single high dose (10-5 M). The moderate anticancer activity was shown against some types of cancer on the individual human cell lines for leukemia, non-small cell lung cancer and renal cancer.

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