234077-99-7Relevant academic research and scientific papers
Total synthesis of optically active liverwort sesquiterpenes, trifarienols A and B, using phenylethylamine as a chiral auxiliary
Tori, Motoo,Hisazumi, Kenji,Wada, Tomonari,Sono, Masakazu,Nakashima, Katsuyuki
, p. 961 - 971 (1999)
The imine of (rac)-2,3-dimethylcyclohexanone 10a with (S)-(-)- phenylethylamine was reacted with methyl acrylate to yield methyl (1'S,6'R)- 3-(1',6'-dimethyl-2'-oxocyclohexyl)propanoate 4a in 26% (97% ee) after hydrolysis. When (2RS,3R)-2,3-dimethylcycloh
Total Synthesis and Structure Revision of Halioxepine
Poock, Caroline,Kalesse, Markus
supporting information, p. 1615 - 1619 (2020/12/23)
The first total synthesis of halioxepine is accomplished using a 1,4-addition for constructing the quaternary center at C10 and a halo etherification for the generation of the tertiary ether at C7. The correct structure of halioxepine was determined by assembling different enantiomeric building blocks and by changing the relative configuration between C10 and C15.
