234081-96-0Relevant articles and documents
Agents for alkylating steroid hormone receptors. 3. Omega-substituted esters of 17-alpha-hydroxyprogesterone.
Solo,Gardner
, p. 1089 - 1092 (1971)
The synthesis and Clauberg activity of the 8-carbomethoxyoctanoate (IIe), 9-carbomethoxynonanoate (IIf), 9-carboethoxynonanoate (IIg), 9-carbo-tert-butoxynonanoate (IIh), 8-carboxyoctanoate (IIId), 9-oxo-10-diazodecanoate (IVd), 5-oxo-6-hydroxyhexanoate (Va), and 6-oxo-7-hydroxyheptanoate (Vb) esters of 17-alpha-hydroxyprogesterone are reported in this article. Esters IIa-IIe and IIe-IIh were tested by the McPhail modification of the Clauberg assay. The progestational activity increased with chain length for the glutarate ester IIa through the pimelate ester IIe. It then decreased slightly for the azelate ester IIe and decreased further for the methyl and tert-butyl sebacates IIf and IIh.
Synthetic method of octadecanedioic acid mono-tert-butyl ester
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, (2020/11/22)
The invention relates to the field of organic synthesis, in particular to a synthesis method of octadecanedioic acid mono-tert-butyl ester, which comprises the following steps: carrying out reflux esterification on sebacic acid and methanol to obtain octadecanedioic acid monomethyl ester, reacting the octadecanedioic acid monomethyl ester with isobutene under the action of a composite catalyst, concentrating, alkalizing the concentrated solution, extracting, drying and filtering. Compared with the prior art, the method has the advantages that the selectivity is good, the reaction conversion rate is high, the total yield of a final product reaches 96% or above, and the purity reaches 95% or above. The adopted composite catalyst is different from a traditional acid catalyst, Fe is dopedin bismuth vanadate, bismuth vanadate crystal lattices can be introduced into defect positions, the crystallinity is changed, and the proton or electron trapping capacity of a semiconductor can be enhanced; photocatalyst activity is improved, the bismuth vanadate is loaded on the surface of lignin amine to form a core/membrane structure used for catalyzing esterification of carboxylic acid and olefin, and the catalyst can be separated and recycled by means of magnetic separation and the like, and can be repeatedly used for multiple times without reduction in catalytic effect.
MODIFIED RELAXIN POLYPEPTIDES COMPRISING A PHARMACOKINETIC ENHANCER AND USES THEREOF
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Paragraph 0350-0351; 0352, (2018/08/25)
The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
Trigger lipids inducing pH-dependent liposome fusion
Ogawa, Yoshikatsu,Kodaka, Masato,Okuno, Hiroaki
, p. 51 - 68 (2007/10/03)
Aspartic acid-derived artificial lipids (ADLs; s indicates the number of the methylene groups, s=2, 4, 6, 8, 10, 12) (Scheme 1) with various carboxyl alkyl chains as head groups are designed and synthesized, which are incorporated into liposome membranes by sonication. Fluorescence resonance energy transfer (FRET) measurements indicate that ADL6, ADL8 and ADL10 have high lipid-mixing ability in the acidic solution. The other ADLs, however, do not induce remarkable liposome fusion at acidic nor neutral pH. The hydrophobicity of the head groups of ADL6, ADL8 and ADL10 is suitable as triggers of membrane fusion.
Non-peptidic liposome-fusion compounds at acidic pH
Ogawa, Yoshikatsu,Tomohiro, Takenori,Yamazaki, Yoshimitsu,Kodaka, Masato,Okuno, Hiroaki
, p. 823 - 824 (2007/10/03)
Liposomes including aspartic acid-derived artificial lipids (ADL) with various carboxy alkyl chains as head groups (ADLn; n indicates the number of the methylene groups, n = 2,4,6,8,10,12) are prepared, in which ADL6 and ADL8 liposomes induce remarkably high lipid-mixing in the acidic region.