10-(tert-Butoxy)-10-oxodecanoic acid

Base Information

• Chemical Name: 10-(tert-Butoxy)-10-oxodecanoic acid
• CAS No.: 234081-96-0
• Molecular Formula: C14H26O4
• Molecular Weight: 258.358
• Mol file: 234081-96-0.mol

Synonyms:tert-Butyl-9-carboxynonanoat;Decanedioic acid mono-tert-butyl ester;

Chemical Property of 10-(tert-Butoxy)-10-oxodecanoic acid

Chemical Property:

• Boiling Point: 355.9±25.0 °C(Predicted)
• PKA: 4.78±0.10(Predicted)
• PSA: 63.60000
• Density: 1.002±0.06 g/cm3(Predicted)
• LogP: 3.53350
• Storage Temp.: 2-8°C

Purity/Quality:

97%min ^*data from raw suppliers

10-(tert-Butoxy)-10-oxodecanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-(tert-Butoxy)-10-oxodecanoic acid

There total 5 articles about 10-(tert-Butoxy)-10-oxodecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

C15H28O4 → 10-(tert-butoxy)-10-oxodecanoic acid (234081-96-0)

Guidance literature:

With water; sodium hydroxide; at 20 ℃; pH=9 - 10;

Reference yield: 37.0%

1,10-decanedioic acid (111-20-6,26776-29-4) + tert-butyl alcohol (75-65-0) → 10-(tert-butoxy)-10-oxodecanoic acid (234081-96-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1016/S0009-3084(02)00053-1

Reference yield:

1,10-decanedioic acid (111-20-6,26776-29-4) → 10-(tert-butoxy)-10-oxodecanoic acid (234081-96-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 75 - 80 °C

2: Fe(III)-doped bismuth vanadate on ligninamine composite catalyst / -20 - 0 °C

3: sodium hydroxide; water / 20 °C / pH 9 - 10

With sulfuric acid; water; sodium hydroxide;

upstream raw materials:

monoethyl sebacate

isobutene

1,10-decanedioic acid

tert-butyl alcohol

Downstream raw materials:

9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid

9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester

Refernces

• 1、 -. "Synthetic method of octadecanedioic acid mono-tert-butyl ester". Paragraph 0020; 0024-0025; 0029-0030; 0034. . Retrieved 2020/11/22.
• 2、 Ogawa, Yoshikatsu,Kodaka, Masato,Okuno, Hiroaki. "Trigger lipids inducing pH-dependent liposome fusion". . p. 51 - 68. Retrieved 2007/10/03.