2341-25-5

Usage

Uses

Used in Pharmaceutical Industry:
6-Fluoroindole-3-acetonitrile is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. The presence of the fluoro and acetonitrile groups enhances the compound's reactivity and bioactivity, making it a promising candidate for medicinal chemistry applications.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Fluoroindole-3-acetonitrile serves as an intermediate in the production of agrochemicals, contributing to the development of effective and novel pesticides or other agricultural chemicals. Its unique structural features allow for the creation of compounds with specific target pest control properties.
Used in Organic Chemistry:
6-Fluoroindole-3-acetonitrile is utilized as a building block in organic chemistry reactions due to its reactive functional groups. It facilitates the synthesis of a wide range of organic compounds, expanding the scope of chemical research and the development of new materials and molecules with potential applications in various fields.
Used in Research and Development:
6-Fluoroindole-3-acetonitrile is employed in research and development settings to explore its potential applications and to understand its chemical behavior. 6-fluoroindole-3-acetonitrile's unique properties make it an interesting subject for scientific inquiry, potentially leading to breakthroughs in synthetic methods and the discovery of new chemical entities.

InChI:InChI=1/C10H7FN2/c11-8-1-2-9-7(3-4-12)6-13-10(9)5-8/h1-2,5-6,13H,3H2

Upstream product

• 343-93-1 1-(6-fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 151-50-8 potassium cyanide 
• 77-78-1 dimethyl sulfate 
• 773837-37-9 sodium cyanide 
• 1219945-13-7 1-(6-fluoro-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodide 
• 399-51-9 6-fluoro-1H-indole 
• 74-88-4 methyl iodide 
• 7677-24-9 trimethylsilyl cyanide 
• 350-78-7 3-fluoro-isonitrosoacetanilide 
• 372-19-0 meta-fluoroaniline 
• 446-10-6 2-nitro-4-fluorotoluene 

Downstream Products

• 443-75-4 2-(6-fluoro-1H-indol-3-yl)acetic acid 
• 467458-02-2 [2-(6-fluoro-1H-indol-3-yl)ethyl]({[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl})amine HCl salt 
• 61-54-1 tryptamine 
• 575-85-9 6-fluorotryptamine 

Relevant academic research and scientific papers

Stereoselective Cascade Cyclizations with Samarium Diiodide to Tetracyclic Indolines: Precursors of Fluorostrychnines and Brucine

A series of γ-indolylketones with fluorine, cyano or alkoxy substituents at the benzene moiety was prepared and subjected to samarium diiodide-promoted cyclization reactions. The desired dearomatizing ketyl cascade reaction forming two new rings proceeded

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst

Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole ring are well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water is essential, and its possible role is discussed.

A NOVEL PROCESS FOR THE PREPARATION OF TRYPTAMINES AND DERIVATIVES THEREOF

The present invention relates to a novel process for the preparation of tryptamine, its substituted derivatives and intermediates for the preparation of them.

PROCESS FOR THE MANUFACTURE OF IDALOPIRDINE

Disclosed herein is a process for the preparation of idalopirdine and pharmaceutically acceptable salts thereof.

NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES

The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.

PROCESSES FOR THE MANUFACTURE OF A PHARMACEUTICALLY ACTIVE AGENT

Disclosed herein are processes for the preparation of a pharmaceutically active agent and pharmaceutically acceptable salts thereof.

1,2,3,6-TETRAHYDROAZEPINO[4,5-B]INDOLE-5-CARBOXYLATE NUCLEAR RECEPTOR INHIBITORS

Provided are certain 1,2,3,6- tetrahydroazepino[4,5-b]indole-5-carboxylate compounds which are useful for modulating the activity of nuclear receptors, such as farnesoid X receptors, and/or for the treatment, prevention, or amelioration diseases or disorders related to the activity of these receptors.