234114-65-9Relevant academic research and scientific papers
Scope of the intramolecular titanocene-catalyzed Pauson-Khand type reaction
Hicks, Frederick A.,Kablaoui, Natasha M.,Buchwald, Stephen L.
, p. 5881 - 5898 (2007/10/03)
A Pauson-Khand type conversion of enynes to bicyclic cyclopentenones employing the commercially available precatalyst titanocene dicarbonyl is described. This methodology shows excellent functional group tolerance for a group 4 metallocene-catalyzed process. The scope and limitations of this cyclization with respect to 1,6-, 1,7- and 1,8-enynes with a variety of terminal alkyne substituents, chiral enynes, and enynes containing substituted olefins are described in detail. A mechanism involving carbonylation of an intermediate titanacyclopentene has been proposed.
