23429-74-5

Usage

Uses

Used in Organic Synthesis:
1-(4-BROMOPHENYL)-3-HYDROXY-1H-PYRAZOLE is used as a key intermediate in the synthesis of various heterocyclic compounds due to its unique structural features, including the bromine atom and the hydroxy group. Its ability to form new chemical bonds and participate in reactions makes it a valuable component in creating a wide range of biologically active molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(4-BROMOPHENYL)-3-HYDROXY-1H-PYRAZOLE is utilized as a starting material for the development of new drugs and biologically active compounds. Its structural diversity and potential for modification allow researchers to explore its properties and applications in creating novel therapeutic agents.
Used in Coordination Chemistry:
1-(4-BROMOPHENYL)-3-HYDROXY-1H-PYRAZOLE serves as a ligand in coordination chemistry, playing a crucial role in the formation and stabilization of metal complexes. Its presence can influence the properties and reactivity of these complexes, making it an important component in the design and synthesis of new materials with potential applications in various fields, including catalysis and drug design.
Used in the Preparation of Metal Complexes:
This versatile compound is also employed in the preparation of metal complexes, where it can enhance the stability, solubility, and reactivity of the resulting complexes. The ability of 1-(4-BROMOPHENYL)-3-HYDROXY-1H-PYRAZOLE to form stable complexes with various metal ions makes it a valuable tool in the development of new materials with potential applications in areas such as electronics, sensors, and pharmaceuticals.

Upstream product

• 622-88-8 4-bromophenylhydrazine hydrochloride 
• 106-40-1 4-bromo-aniline 
• 24834-98-8 1-(4-bromophenyl)pyrazolidin-3-one 

Downstream Products

• 1257339-00-6 3-(2-((1-(4-bromophenyl)-2H-pyrazol-3-yloxy)methyl)phenyl)oxazolidin-2-one 
• 478919-58-3 1-(4-bromophenyl)-1,2-dihydro-3H-pyrazole-3-thion 

Relevant academic research and scientific papers

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.

Synthesis, fungicidal activity, structure-activity relationship and density functional theory studies of novel oxime ether derivatives containing 1-aryl-3-oxypyrazoles

A series of 16 oxime ether derivatives containing 1-aryl-3-oxypyrazoles were synthesised, and the structure of one of them, (E)-methyl 2-(2-({(1-(4-chlorophenyl)-1H-pyrazol-3-yl)-oxy}methyl)phenyl)-2-(methoxyimino)acetate was determined by X-ray diffraction crystallography. Preliminary bioassays indicated that some of these compounds exhibited very good fungicidal activities against Rhizoctonia solani, especially the ester 2-(2-({(1-(4-chlorophenyl)-1H-pyrazol-3-yl)-oxy}methyl)phenyl)-2-(methoxyimino)acetate, which displayed greater activity than control compound pyraclostrobin at a dosage of 0.1 μg mL-1. The relationship between structure and fungicidal activity was discussed. Density functional theory studies of the 3-methyl heterocyclic ester and the 4-chorophenyl heterocyclic N-methylamide were carried out and the results discussed in terms of the wide difference in fungicidal activity shown by each compound.

TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES

The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1): [wherein R1 represents an C6-C16 aryl group, an C1-C12 alkyl group, or a C3-C12 cycloalkyl group, etc., which each optionally be substituted; R2, R3, R4 and R5 represent independently of each other a hydrogen atom, a halogen atom or an C1-C3 alkyl group, etc.; R6 represents an C1-C6 alkyl group, a C3-C6 cycloalkyl group, a halogen atom, a C1-C6 haloalkyl group, an C2-C6 alkenyl group, an C1-C6 alkoxy group, or a C1-C6 haloalkoxy group, etc.; R7, R8 and R9 represent independently of each other a hydrogen atom, a halogen atom, or an C1-C4 alkyl group, etc.; X represents an oxygen atom or a sulfur atom; and R10 represents an C1-C6 alkyl group, etc.] shows an excellent controlling efficacy on pests.

Synthesis, crystal structure and fungicidal activities of new type oxazolidinone-based strobilurin analogues

A series of oxazolidinone-based strobilurin analogues were efficiently synthesized by the reaction of 3-(2-bromomethylphenyl) oxazolidin-2-one with 1-substituted phenyl-2H-pyrazolin-3-one. Their structures were confirmed and characterized by 1H-NMR, 13C-NMR, elemental analysis, and mass spectroscopy. In addition, the crystal structure of the target compound 3-(2-((1-phenyl-2H-pyrazol-3-yloxy)methyl)phenyl) oxazolidin-2-one was determined by single crystal X-ray diffraction. The bioassay results of these compounds indicated that some of the oxazolidin-2-one derivatives containing N-substituted phenyl 2H-pyrazol ring exhibited potential in vivo fungicidal activities against M. grisea at the dosage of 1 g L-1.