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Usage

Uses

Used in Pharmaceutical Industry:
1-(4-BROMOPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE is used as a pharmaceutical compound for its potential anti-inflammatory and analgesic properties. Its unique structure allows it to be a promising candidate for the development of new medications to treat various conditions that involve inflammation and pain.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(4-BROMOPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE is used as a research compound to study its biological activities and potential interactions with biological targets. This research can lead to a better understanding of the compound's mechanisms of action and its potential as a therapeutic agent.
Used in Drug Discovery:
1-(4-BROMOPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE is also used in drug discovery processes. Its unique structure and biological activities make it a valuable starting point for the development of new drugs targeting inflammation and pain. Through further optimization and modification, 1-(4-BROMOPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE may lead to the creation of more effective and safer medications for patients.

Upstream product

• 107-13-1 acrylonitrile 
• 589-21-9 (4-bromophenyl)hydrazine 
• 622-88-8 4-bromophenylhydrazine hydrochloride 
• 140-88-5 ethyl acrylate 
• 106-40-1 4-bromo-aniline 
• 64-17-5 ethanol 
• 292638-85-8 acrylic acid methyl ester 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 1257339-00-6 3-(2-((1-(4-bromophenyl)-2H-pyrazol-3-yloxy)methyl)phenyl)oxazolidin-2-one 
• 23429-74-5 1-(4-bromophenyl)-1H-pyrazole-3-ol 
• 23429-74-5 1-(4-bromophenyl)-1,2-dihydro-3H-pyrazol-3-one 

Relevant academic research and scientific papers

A convenient one-pot synthesis of 1-aryl-substituted 4-iodopyrazol-3-ols via aromatisation and oxidative iodination reactions

A convenient and economical one-pot synthesis of a series of new 1-aryl-substituted 4-iodopyrazole-3-ols from easily available pyrazolidin- 3-ones in the presence of sodium iodide, 30% solution of hydrogen peroxide and a catalytic amount of sulfuric acid in dichloromethane via aromatisation and oxidative iodination reactions are described. This protocol has the advantages of high atom economy, costeffectiveness, short reaction time and environmental friendliness.

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.

Synthesis, fungicidal activity, structure-activity relationship and density functional theory studies of novel oxime ether derivatives containing 1-aryl-3-oxypyrazoles

A series of 16 oxime ether derivatives containing 1-aryl-3-oxypyrazoles were synthesised, and the structure of one of them, (E)-methyl 2-(2-({(1-(4-chlorophenyl)-1H-pyrazol-3-yl)-oxy}methyl)phenyl)-2-(methoxyimino)acetate was determined by X-ray diffraction crystallography. Preliminary bioassays indicated that some of these compounds exhibited very good fungicidal activities against Rhizoctonia solani, especially the ester 2-(2-({(1-(4-chlorophenyl)-1H-pyrazol-3-yl)-oxy}methyl)phenyl)-2-(methoxyimino)acetate, which displayed greater activity than control compound pyraclostrobin at a dosage of 0.1 μg mL-1. The relationship between structure and fungicidal activity was discussed. Density functional theory studies of the 3-methyl heterocyclic ester and the 4-chorophenyl heterocyclic N-methylamide were carried out and the results discussed in terms of the wide difference in fungicidal activity shown by each compound.

Synthesis, crystal structure and fungicidal activities of new type oxazolidinone-based strobilurin analogues

A series of oxazolidinone-based strobilurin analogues were efficiently synthesized by the reaction of 3-(2-bromomethylphenyl) oxazolidin-2-one with 1-substituted phenyl-2H-pyrazolin-3-one. Their structures were confirmed and characterized by 1H-NMR, 13C-NMR, elemental analysis, and mass spectroscopy. In addition, the crystal structure of the target compound 3-(2-((1-phenyl-2H-pyrazol-3-yloxy)methyl)phenyl) oxazolidin-2-one was determined by single crystal X-ray diffraction. The bioassay results of these compounds indicated that some of the oxazolidin-2-one derivatives containing N-substituted phenyl 2H-pyrazol ring exhibited potential in vivo fungicidal activities against M. grisea at the dosage of 1 g L-1.