24834-98-8

Basic information

• Product Name: 1-(4-BROMOPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE
• Synonyms: 1-(4-BROMOPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE
• CAS NO: 24834-98-8
• Molecular Formula: C₉H₉BrN₂O
• Molecular Weight: 241.08
• Mol File: 24834-98-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-BROMOPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE(24834-98-8)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE(24834-98-8)

Safety Data

• Hazardous Substances Data: 24834-98-8(Hazardous Substances Data)

Usage

General Description

1-(4-Bromophenyl)-3-hydroxy-4,5-dihydro-1H-pyrazole is a chemical compound with the molecular formula C9H9BrN2O. It is a pyrazole derivative with a hydroxy group attached to the third position of the pyrazole ring and a bromine atom attached to the 4th position of the phenyl group. 1-(4-BROMOPHENYL)-3-HYDROXY-4,5-DIHYDRO-1H-PYRAZOLE has potential applications in the pharmaceutical industry as it exhibits interesting biological activities, such as anti-inflammatory and analgesic properties. Its structure and properties make it a promising candidate for further research and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 64-17-5 ethanol 
• 622-88-8 4-bromophenylhydrazine hydrochloride 
• 292638-85-8 acrylic acid methyl ester 
• 625-36-5 2-chloropropionyl chloride 
• 106-40-1 4-bromo-aniline 
• 140-88-5 ethyl acrylate 
• 107-13-1 acrylonitrile 
• 589-21-9 (4-bromophenyl)hydrazine 

Downstream Products

• 23429-74-5 1-(4-bromophenyl)-1,2-dihydro-3H-pyrazol-3-one 
• 23429-74-5 1-(4-bromophenyl)-1H-pyrazole-3-ol 
• 1257339-00-6 3-(2-((1-(4-bromophenyl)-2H-pyrazol-3-yloxy)methyl)phenyl)oxazolidin-2-one 

Relevant articles and documents

A convenient one-pot synthesis of 1-aryl-substituted 4-iodopyrazol-3-ols via aromatisation and oxidative iodination reactions

A convenient and economical one-pot synthesis of a series of new 1-aryl-substituted 4-iodopyrazole-3-ols from easily available pyrazolidin- 3-ones in the presence of sodium iodide, 30% solution of hydrogen peroxide and a catalytic amount of sulfuric acid in dichloromethane via aromatisation and oxidative iodination reactions are described. This protocol has the advantages of high atom economy, costeffectiveness, short reaction time and environmental friendliness.

Synthesis, fungicidal activity, structure-activity relationship and density functional theory studies of novel oxime ether derivatives containing 1-aryl-3-oxypyrazoles

A series of 16 oxime ether derivatives containing 1-aryl-3-oxypyrazoles were synthesised, and the structure of one of them, (E)-methyl 2-(2-({(1-(4-chlorophenyl)-1H-pyrazol-3-yl)-oxy}methyl)phenyl)-2-(methoxyimino)acetate was determined by X-ray diffraction crystallography. Preliminary bioassays indicated that some of these compounds exhibited very good fungicidal activities against Rhizoctonia solani, especially the ester 2-(2-({(1-(4-chlorophenyl)-1H-pyrazol-3-yl)-oxy}methyl)phenyl)-2-(methoxyimino)acetate, which displayed greater activity than control compound pyraclostrobin at a dosage of 0.1 μg mL-1. The relationship between structure and fungicidal activity was discussed. Density functional theory studies of the 3-methyl heterocyclic ester and the 4-chorophenyl heterocyclic N-methylamide were carried out and the results discussed in terms of the wide difference in fungicidal activity shown by each compound.